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Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages throughα-ketoglutarate and mTORC1 signaling被引量：2: 《Cellular & Molecular Immunology》2024年第5期448-465,共18页Zhengnan Cai Wan Li Sonja Hager Jayne Louise Wilson Leila Afjehi-Sadat Elke HHeiss Thomas Weichhart Petra Heffeter Wolfram Weckwerth; Phosphoglycerate dehydrogenase(PHGDH)has emerged as a crucial factor in macromolecule synthesis,neutralizing oxidative stress,and regulating methylation reactions in cancer cells,lymphocytes,and endothelial cells.Howe...; 关键词：PHGDH de novo serine synthesis Α-KETOGLUTARATE mTORC1 protumorigenic tumor-associated macrophages metabolomics

AbnI:Anα-ketoglutarate-dependent dioxygenase involved in brassicicene C-H functionalization and ring system rearrangement: 《Chinese Chemical Letters》2024年第5期213-217,共5页Wenling Yuan Fengli Li Zhe Chen Qiaoxin Xu Zhenhua Guan Nanyu Yao Zhengxi Hu Junjun Liu Yuan Zhou Ying Ye Yonghui Zhang; financially supported by the National Key R&D Program of China(Nos.2021YFA0910500,2021YFA0910503);the National Natural Science Foundation of China(Nos.22277035,32000045 and 81973205);the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Fundamental Research Funds for the Central Universities(No.2020kfyXJJS043).; We reported the characterization of a novel brassicicene diterpene biosynthetic gene cluster,which contains a uniqueα-ketoglutarate-dependent dioxygenase(αKGD)enzyme,AbnI.Our findings revealed that AbnI demonstrates...; 关键词：Fungal diterpenes α-Ketoglutarate-dependent dioxygenase C-H functionalization REARRANGEMENT Brassicicenes

IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbingα-ketoglutarate-related metabolism and epigenetic modification: 《Life Metabolism》2024年第2期24-37,共14页Yuanlin Zhao Ying Yang Risheng Yang Chao Sun Xing Gao Xiwen Gu Yuan Yuan Yating Nie Shenhui Xu Ruili Han Lijun Zhang Jing Li Peizhen Hu Yingmei Wang Huangtao Chen Xiangmei Cao Jing Wu Zhe Wang Yu Gu Jing Ye; supported by funds from the National Key Research and Development Program of China(2022YFA0806501);the National Natural Science Foundation of China(81972342 to J.Y.,82173120 to Y.G.,and 82070298 to L.Z.);the Natural Science Basic Research Plan in ShaanxiProvince(2020JZ-29 to J.Y.).; Isocitrate dehydrogenase(IDH)mutations frequently occur in lower-grade gliomas and secondary glioblastomas.Mutant IDHs exhibit a gain-of-function activity,leading to the production of D-2-hydroxyglutarate(D-2HG)by red...; 关键词：Α-KETOGLUTARATE IDH1 mutation OGDH L-GLUTAMINE gliomas

Establishing Modular Cell-Free Expression System for the Biosynthesis of Bicyclomycin from a Chemically Synthesized Cyclodipeptide: 《Chinese Journal of Chemistry》2024年第4期384-390,共7页Yi-Pei Liu Yu-Heng Zhao Wen-Qi Zhang Lian Wu Linjuan Huang Gong-Li Tang Jun-Bin He; supported in part by grants from the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(22207117).; Cell-free expression systems have emerged as a versatile and powerful platform for metabolic engineering,biosynthesis and synthetic biology studies.Nevertheless,successful examples of the synthesis of complex natural ...; 关键词：Natural products Bicyclomycin BIOSYNTHESIS Iron-andα-ketoglutarate-dependent dioxygenases Cytochrome P450 monooxygenase Cell-freeprotein synthesis Enzyme catalysis

α-Ketoglutarate dehydrogenase(KGDH):A new balancer between energy metabolism and gene expression in plants: 《Journal of Integrative Plant Biology》2023年第8期1843-1845,共3页Wenwen Zhu Yikun He; Sessile plants can adjust their growth and development in response to environmental stimuli.Sunlight(light),is the primary source of energy for all life on the earth,in the long course of phylogenetic evolution,plants...; 关键词：energy METABOLISM CONVERT

QM/MM study on the O_(2)activation reaction of 4-hydroxylphenyl pyruvate dioxygenase reveals a common mechanism forα-ketoglutarate dependent dioxygenase: 《Chinese Chemical Letters》2023年第5期461-465,共5页Linhui Li Suitian Lai Hongyan Lin Xinyun Zhao Xin Li Xi Chen Junjun Liu Guangfu Yang Changguo Zhan; supported by the National Key R&D Program(No.2021YFD1700100);National Natural Science Foundation of China(Nos.21837001,21273089);the Open Project Fund of the Key Laboratory of the Pesticides and Chemical Biology of Central China Normal University(No.2018-A01);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the South-Central University for Nationalities(No.CZW20020)。; The dioxygen activation catalyzed by 4-hydorxylphenyl pyruvate dioxygenase(HPPD)were reinvestigated by using hybrid quantum mechanics/molecular mechanics(QM/MM)approaches at the B3LYP/6-311++G(d,p):AMBER level.These s...; 关键词：4-Hydroxylphenyl pyruvate dioxygenase O_(2)activation QM/MM Mechanism Minimum energy crossing point

Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia被引量：3: 《Chinese Journal of Cancer Research》2021年第3期308-322,共15页Duo You Danfeng Du Xueke Zhao Xinmin Li Minfeng Ying Xun Hu; supported in part by the China Natural Sciences Foundation projects (No. 81772947)。; Objective: α-ketoglutarate(α-KG) is the substrate to hydroxylate collagen and hypoxia-inducible factor-1α(HIF-1α), which are important for cancer metastasis. Previous studies have shown that the upregulation of co...; 关键词：Malic enzyme 2 breast cancer METASTASIS MALATE Α-KETOGLUTARATE hypoxia-inducible factor-1α

α-ketoglutarate promotes the specialization of primordial germ cell-like cells through regulating epigenetic reprogramming被引量：1: 《The Journal of Biomedical Research》2021年第1期36-46,I0014-I0016,共14页Ming Xing Na Wang Hanyi Zeng Jun Zhang; supported by grants from the National Natural Science Foundation of China(No.31871445 and No.31501211);the National Key R&D program of China(No.2017YFC1001302 and No.2016YFA0503300)。; There is growing evidence that cellular metabolism can directly participate in epigenetic dynamics and consequently modulate gene expression.However,the role of metabolites in activating the key gene regulatory networ...; 关键词：cellular metabolism Α-KETOGLUTARATE primordial germ cells EPIGENOME

Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors被引量：1: 《World Journal of Gastroenterology》2020年第34期5074-5089,共16页Yue Zhao Fei Feng Qing-Hong Guo Yu-Ping Wang Rui Zhao; Science and Technology Program of Gansu Province Grant,No.18JR3RA339 and No.18JR3RA363;Fund of the First Hospital of Lanzhou University Grant,No.ldyyyn2018-63;Teaching and Research Project of the First Clinical Medical College of Lanzhou University in 2018 Grant,No.2018007;NIH awards,No.R21NS106430 and No.R01OD026594;Cystic Fibrosis Foundation Research Grant,No.ZHAO19G0;an American Cancer Society-IRG Junior Faculty Development Grant,a UAB CCC Neuro-oncology Research Acceleration Grant,and a UAB Faculty Development Grant Program Award.; Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.At the molecular level,GISTs can be categorized into two groups based on the causative oncogenic mutations.App...; 关键词：Gastrointestinal stromal tumors Succinate dehydrogenase Oncometabolite SUCCINATE α-ketoglutarate-dependent dioxygenase EPIGENETICS

Discovery of a novel calcium-sensitive fluorescent probe for α-ketoglutarate: 《Acta Pharmacologica Sinica》2017年第12期1683-1690,共8页Lin-lin GAN Lin-hai CHEN Fa-jun NAN; α-Ketoglutarate （α-KG）, a pivotal metabolite in energy metabolism, has been implicated in nonalcoholic fatty liver disease （NAFLD） and several cancers. It is recently proposed that plasma α-KG is a surrogate bi...; 关键词：nonalcoholic fatty liver disease biomarker Α-KETOGLUTARATE fluorescent probe calcium-sensitive benzothiazole-coumarin

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