METFORMIN

作品数:365被引量:985H指数:15
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相关机构:四川农业大学南京大学南方医科大学广东医科大学更多>>
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Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways被引量:4
《Acta Pharmacologica Sinica》2021年第4期604-612,共9页Miao Yu Zhi-xiao Fang Wei-wei Wang Ying Zhang Zhi-lei Bu Meng Liu Xin-hua Xiao Zi-lu Zhang Xing-ming Zhang Yang Cao Ying-ying Wang Hu Lei Han-zhang Xu Yun-zhao Wu Wei Liu Ying-li Wu 
supported in part by grants from the National Key Research and Development Program of China(No.2017YFA0505202);the National Basic Research Program of China(973 Program)(No.2015CB910403);the National Natural Science Foundation of China(Nos.81570118,81700475,81570112,81670139,and 21602133);the National Natural Science Foundation Youths of China(No.81700157);Innovative research team of high-level local universities in Shanghai(SSMU-ZDCX20181202).
The kinase FLT3 internal tandem duplication(FLT3-ITD)is related to poor clinical outcomes of acute myeloid leukemia(AML).FLT3 inhibitors have provided novel strategies for the treatment of FLT3-ITD-positive AML.But th...
关键词:AML Wu-5 crenolanib USP10 FLT3-ITD AMPKα Compound C METFORMIN 
Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy被引量:14
《Nano Research》2017年第4期1200-1212,共13页Xuejiao Song Liangzhu Feng Chao Liang Min Gao Guosheng Song Zhuang Liu 
Acknowledgements This work was partially supported by the National Basic Research Program of China (973 Program) (No. 2012CB932600), the National Natural Science Foundation of China (Nos. 51525203 and 51132006), a Jiangsu Natural Science Fund for Distinguished Young Scholars (No. BK20130005), Collaborative Innovation Center of Suzhou Nano Science and Technology, and a Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
Though photodynamic therapy (PDT) has been widely used in the non-invasive destruction of solid tumors, the therapeutic efficacy of PDT is often limited by the hypoxic tumor environment. Herein, we report the innova...
关键词:photodynamic therapy liposomes metforrnin tumor hypoxia 
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