PALMITOYLATION

作品数：31被引量：92H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：林芳王雁秦正红更多>>
相关机构：浙江大学苏州大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Frontiers of Medicine》《Zoological Research》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山西省自然科学基金更多>>
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ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification被引量：1
《Frontiers of Medicine》2023年第4期685-698,共14页Wenle Ye Jinghan Wang Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang Jiajia Pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin 
supported by the key international cooperation projects of the National Natural Science Foundation of China(No.81820108004);the major projects of the Zhejiang Provincial Department of Science and Technology(No.2021C03123);the Pediatric Leukemia Diagnosis and Therapeutic Technology Research Center of Zhejiang Province(No.JBZX-201904).
Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5...
关键词：acute myeloid leukemia acyl-CoA synthetase long chain family member 5 WNT3A PALMITOYLATION ABT-199 
Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma
《Frontiers of Medicine》2022年第5期784-798,共15页Yan Zhang Baoyuan Zhang Yongyun Li Yuting Dai Jiaoyang Li Donghe Li Zhizhou Xia Jianming Zhang Ping Liu Ming Chen Bo Jiao Ruibao Ren 
This work was supported by the Key Project of National Natural Science Foundation of China(No.81530006 to Ruibao Ren);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to Ruibao Ren);National Natural ScienceFoundation of China(No.81870112 to Ruibao Ren,No.81770171 to Bo Jiao,and No.81970134 to Ping Liu);Samuel Waxman Cancer Research Foundation(to Ruibao Ren);the Innovative Research Team of High-level Local Universities in Shanghai.
More than 85%of patients with uveal melanoma(UM)carry a GNAQ or GNA11 mutation at a hotspot codon(Q209)that encodes G proteinαsubunit q/11 polypeptides(Gα_(q/11)).GNAQ/11 relies on palmitoylation for membrane associ...
关键词：uveal melanoma mutant GNAQ/11 PALMITOYLATION BCL2 combination target therapy 
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