DIFLUNISAL

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相关领域：医药卫生更多>>
相关作者：靳亚峰刘璐李东浩更多>>
相关机构：延边大学更多>>
相关期刊：《Infectious Microbes & Diseases》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Repurposing Diflunisal as an Antivirulence Agent Against Staphylococcus aureus
《Infectious Microbes & Diseases》2025年第1期43-53,共11页Daniel Sun Nina M.Haste Josh Sun Mateus SáMagalhães Serafim Anna Salvioni Joshua Olson Jason Cole Cheryl Okumura Richard L.Gallo George Sakoulas Anthony J.O’Donoghue Mary E.Hensler Victor Nizet 
supported by the US National Institutes of Health grants(R01-AI145325);This work was also supported in part by the UCSD Graduate Training Program in Cellular and Molecular Pharmacology through an institutional training grant from the National Institute of General Medical Sciences,T32 GM007752;The funder had no role in the study design,data collection or analysis,decision to publish,or preparation of the manuscript.MSMS acknowledges his PDE scholarship by CNPq(200069/2024-1).
Infections refractory to standard antibiotic therapy are contributing to adverse treatment outcomes in patients suffering from deep-seated bacterial infections caused by increasingly resistant pathogens.Adjunctive str...
关键词：Staphylococcus aureus DIFLUNISAL nonsteroidal anti-inflammatory drug drug repurposing antivirulence therapy antimicrobial peptides alpha-toxin BIOFILM 
Crystalline inclusion complexes formed between the drug diflunisal and block copolymers
《Chinese Chemical Letters》2017年第6期1268-1275,共8页Zhi Zhong Xiaotong Yang Xiao-Bin Fu Ye-Feng Yao Bao-Hua Guo Yanbin Huang Jun Xu 
financially supported by the National Natural Science Foundation of China(Nos.21434008,21374054);National Basic Research Program of China(973 Program,No.2014CB932202)
The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certa...
关键词：Pharmaceutical solid forms Inclusion complexes Drugs Block copolymers Thermal stability Aqueous solubility Dissolution profiles 
Synthesis and anti-inflammatory-analgesic activity of 2',4'-difluoro-3-(carbamoyl)biphenyl-4-yl benzoates
《Chinese Chemical Letters》2008年第12期1419-1422,共4页Guang Xiang Zhong Lu Lu Chen Jian Li Wei Xiao Hu Min You Qi 
the Opening Foundation of The Biochemical Engineering Key Discipline (No.20050105) Zhejiang,China,for financial support;the National Center for Drug Screening,Shanghai,China,for evaluation of anti-inflammatory and analgesic activity.
Eighteen 2′,4′-difluoro-3-（carbamoyl）biphenyl-4-yl benzoates were synthesized from diflunisal in three steps with total yields from 72% to 86%. All compounds were identified by IR, 1^H NMR, MS and elemental analys...
关键词：2′ 4′-Difluoro-3-（carbamoyl）biphenyl-4-yl benzoate Anti-inflammatory activity Analgesic activity DIFLUNISAL 
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