DIFLUNISAL

作品数：3被引量：0H指数：0
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相关领域：医药卫生更多>>
相关作者：靳亚峰刘璐李东浩更多>>
相关机构：延边大学更多>>
相关期刊：《Infectious Microbes & Diseases》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Crystalline inclusion complexes formed between the drug diflunisal and block copolymers
《Chinese Chemical Letters》2017年第6期1268-1275,共8页Zhi Zhong Xiaotong Yang Xiao-Bin Fu Ye-Feng Yao Bao-Hua Guo Yanbin Huang Jun Xu 
financially supported by the National Natural Science Foundation of China(Nos.21434008,21374054);National Basic Research Program of China(973 Program,No.2014CB932202)
The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certa...
关键词：Pharmaceutical solid forms Inclusion complexes Drugs Block copolymers Thermal stability Aqueous solubility Dissolution profiles 
Synthesis and anti-inflammatory-analgesic activity of 2',4'-difluoro-3-(carbamoyl)biphenyl-4-yl benzoates
《Chinese Chemical Letters》2008年第12期1419-1422,共4页Guang Xiang Zhong Lu Lu Chen Jian Li Wei Xiao Hu Min You Qi 
the Opening Foundation of The Biochemical Engineering Key Discipline (No.20050105) Zhejiang,China,for financial support;the National Center for Drug Screening,Shanghai,China,for evaluation of anti-inflammatory and analgesic activity.
Eighteen 2′,4′-difluoro-3-（carbamoyl）biphenyl-4-yl benzoates were synthesized from diflunisal in three steps with total yields from 72% to 86%. All compounds were identified by IR, 1^H NMR, MS and elemental analys...
关键词：2′ 4′-Difluoro-3-（carbamoyl）biphenyl-4-yl benzoate Anti-inflammatory activity Analgesic activity DIFLUNISAL 
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