supported by the National Natural Science Foundation of China(81774150,81973506,82104437);Natural Science Foundation of Jiangsu Province(BK20210431);China Postdoctoral Science Foundation(2021M693519);National Innovation and Entrepreneurship Training Program for Undergraduate(202110316013Y);“Double First-Class”University project(CPU2018GF06,CPU2018GF07).
We previously found that the levels of metabolite N-acetylglutamine were significantly increased in urine samples of patients with heart failure(HF)and in coronary artery ligation(CAL)-induced HF mice,whereas the expr...