Acknowledgments We thank Drs Rui-Ming Xu and Qing-Long You (Institute of Biophysics, Chinese Academy of Sciences) for kindly providing the GST-53BP1 plasmid. We also thank the Center for Biomedical Analysis of Tsinghua University for sample analysis. This work was supported by the National Key Research and Development Plan (2017YFA0505200 and 2016YFA0400903) and the National Natu- ral Science Foundation of China (21532004, 81621002, 21621003 and 21708036).
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