supported by the National Natural Science Foundation of China (Nos. 22074088, 21622507, 21904083);the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT_15R43);the Innovation Capability Support Program of Shaanxi (No. 2021TD-42);the Fundamental Research Funds for the Central Universities (Nos. GK202101001 and GK202201009)。
T4 polynucleotide kinase(T4 PNK) is a pivotal enzyme for DNA replication, recombination, and DNA damage repair. Herein, a robust single particle counting-based assay has been developed for the high-sensitive determina...
The acetate of ungeremine (AT-1840, lycobetaine) is a new anticancer agent. Pharmacological studies have revealed that AT-1840 can interact with DNA by intercalation mechanism, preferentially into G-C base pairs. The ...