ERBB2

作品数：182被引量：334H指数：9
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Hallmarks of triple negative breast cancer emerging at last？被引量：3
《Cell Research》2014年第8期904-905,共2页Rosa Bemardi Luca Gianni 
Triple negative breast cancers （TNBC） are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 （ERBB2 or NEU） receptors. Recent evidence shows tha...
关键词：乳腺癌 阴性 恶性肿瘤 ERBB2 内质网应激 ERS 异质性 雌激素 
Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors被引量：2
《Cell Research》2014年第5期542-559,共18页Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu 
Combinatorial targeted therapies are more effective in treating cancer by blocking by-pass mechanisms or inducing synthetic lethality. However, their clinical application is hampered by resistance and toxicity. To mee...
关键词：sequential therapy tumor evolution targeted therapy trastuzumab resistance BEZ235 ErbB2 stabilization 
Identification of novel nuclear localization signal within the ErbB-2 protein被引量：9
《Cell Research》2005年第7期504-510,共7页Qiao Qiao CHEN Xiao Ying CHEN Yun Yun JIANG Jing LIU 
This work was supported by Hi-Tech Research and Development Program of China(2004AA215260).
ErbB2, a member of the receptor tyrosine kinase family, is frequently over-expressed in breast cancer. Proteolysis ofthe extracellular domain of ErbB2 results in constitutive activation of ErbB2 kinase. Recent study r...
关键词：ERBB2 NLS intracellular domain. 
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