Supported by the National Natural Science Foundation of China(No.21503156) and the China Postdoctoral Science Foundation(No.2015M572544).
The bioluminescent mechoafism of colenterazine dioxetanone(CZD) in the photoprotein of Obelia(obelin) was investigated by the combined quantum and molecular mechanics(QM/MM) method at TD-DFT level, which involve...
supported by grants from the National Program on Key Basic Research Project (No. 2013CB734000);the National Natural Science Foundation of China (No. 81370085);the Major Project of Science and Technology of Shandong Province (No. 2015ZDJS04001);the Fundamental Research Funds of Shandong University (No. 2014JC008)
Replacement of the methylene group at the C-8 position with an extended electronic conjugation is a new promising method to develop red-shifted coelenterazine derivatives. In this paper, we have described an oxygen-co...