supported by Shanxi Province Science Foundation for Youths(Grant No.201901D211159);the National Natural Science Foundation of China(Grant Nos.11504214,11874310,and 12090052).
Inositol 1,4,5-trisphosphate receptors(IP_(3)R)-mediated calcium ion(Ca^(2+))release plays a central role in the regulation of cell survival and death.Bcl-2 limits the Ca^(2+)release function of the IP3R through a dir...