RECEPTOR-MEDIATED

作品数：48被引量：183H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：袁玉民许德义孙亚锋胡国渊唐放鸣更多>>
相关机构：中国科学院徐州医学院南京医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划安徽省自然科学基金以色列科学基金更多>>
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Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events
《Acta Pharmaceutica Sinica B》2024年第6期2761-2772,共12页Zhipeng Zeng Runcheng Tan Shi Chen Haolin Chen Zhijia Liu Lixin Liu Mingqiang Li Yongming Chen 
supported by the National Natural Science Foundation of China(No.51820105004,China);the Key Areas Research and Development Program of Guangzhou(No.202007020006,China).
Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic index.Current long-acting insulin analogs...
关键词：Diabetes INSULIN Therapeutic index HYPOGLYCEMIA PEGYLATION Receptor-mediated clearance HALF-LIFE Diabetic nephropathy 
SEL1L preserves CD8^(+) T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis被引量：1
《Cellular & Molecular Immunology》2023年第10期1232-1250,共19页Yafeng Gao Wenhui Li Zhenghao Wang Cangang Zhang Yaping He Xiaowei Liu Kexin Tang Weiguo Zhang Qiaoming Long Yong Liu Jinping Zhang Baojun Zhang Lianjun Zhang 
supported by the National Key R&D Program of China(2022YFA0807300);the National Natural Science Foundation of China(82271775 and 81971466);the Natural Science Foundation Outstanding Youth Fund of Jiangsu Province(BK20220049)and the CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-061,2021-I2M-1-047 and 2022-I2M-2-004).BZ was in part supported by the Innovation Capability Support Program of Shaanxi 2021TD-38.JZ was in part supported by a Translational Research Grant of NCRCH(2020ZKZC04)and the National Natural Science Foundation of China(82071765);supported by the Natural Science Foundation of China(NSFC 31900645).We thank Prof.Yonghong Wan from McMaster University,Canada,for his critical reading of the manuscript and helpful discussions.
SEL1L-mediated endoplasmic reticulum-associated degradation(ERAD)plays critical roles in controlling protein homeostasis by degrading misfolded or terminal unfolded proteins.However,it remains unclear how SEL1L regula...
关键词：T-cell homeostasis Endoplasmic reticulum-associated degradation ER stress response PERK IRE1a 
Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect被引量：4
《Neural Regeneration Research》2023年第6期1371-1377,共7页Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich 
supported by the Department of Anesthesiology and Critical Care,Medical Center-University of Freiburg,Germany;funded by the Baden-Wuerttemberg Ministry of Science,Research and Art and the University of Freiburg in the funding program Open Access Publishing
The noble gas argon has the potential to protect neuronal cells from cell death.So far,this effect has been studied in treatment after acute damage.Preconditioning using argon has not yet been investigated.In this stu...
关键词：apoptosis inflammation INTERLEUKIN-8 neuroprotection ROTENONE SH-SY5Y Toll-like receptor 2 Toll-like receptor 4 
Melatonin Enhances Object Recognition Memory through Melatonin MT1 and MT2 Receptor-Mediated and Non-Receptor-Mediated Mechanisms in Male Mice
《Journal of Behavioral and Brain Science》2022年第12期640-657,共18页Masahiro Sano Hikaru Iwashita Atsuhiko Hattori Atsuhiko Chiba 
Melatonin (MEL) has been reported to have acute enhancing effects on some aspects of cognition. Recently, we revealed that N1-acetyl-5-methoxyquinuramine (AMK), a brain metabolite of MEL, is much more potent than MEL ...
关键词：MELATONIN N1-Acetyl-5-Methoxykynuramine Ramelteon Novel Object Recognition Memory Melatonin Receptors 
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways被引量：3
《World Journal of Gastrointestinal Oncology》2022年第2期450-477,共28页Piao Zheng Zhen Huang Dong-Chang Tong Qing Zhou Sha Tian Bo-Wei Chen Di-Min Ning Yin-Mei Guo Wen-Hao Zhu Yan Long Wei Xiao Zhe Deng Yi-Chen Lei Xue-Fei Tian 
the National Natural Science Foundation of China,No.U20A20408(Major Program)and No.82074450(General Program);Natural Science Foundation of Hunan Province,No.2020JJ4066;Hunan Province Research and innovation projects for Postgraduates,No.CX20190541;Hunan Province"domestic firstclass cultivation discipline"Integrated Traditional Chinese and Western medicine open fund project,No.2018ZXYJH03;Hunan University Undergraduate Research Learning and Innovative Experiment Project,No.201609030114.
BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang Pill.These compounds show anticancer activity in other biological systems.However,whether fr...
关键词：Hepatocellular carcinoma Frankincense Myrrh Network pharmacology Tumor blood vessels Multiple signaling pathways 
Dual mechanisms of Bcl-2 regulation in IP_(3)-receptor-mediated Ca^(2+)release:A computational study被引量：2
《Chinese Physics B》2021年第10期689-697,共9页Hong Qi Zhi-Qiang Shi Zhi-Chao Li Chang-Jun Sun Shi-Miao Wang Xiang Li Jian-Wei Shuai 
supported by Shanxi Province Science Foundation for Youths(Grant No.201901D211159);the National Natural Science Foundation of China(Grant Nos.11504214,11874310,and 12090052).
Inositol 1,4,5-trisphosphate receptors(IP_(3)R)-mediated calcium ion(Ca^(2+))release plays a central role in the regulation of cell survival and death.Bcl-2 limits the Ca^(2+)release function of the IP3R through a dir...
关键词：CA^(2+) BCL-2 bifurcation analysis OSCILLATIONS 
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies被引量：10
《Acta Pharmaceutica Sinica B》2021年第9期2798-2818,共21页Peng Liu Caifang Gao Hongguo Chen Chi Teng Vong Xu Wu Xudong Tang Shengpeng Wang Yitao Wang 
funded by the Science and Technology Development Fund,Macao S.A.R(Grant No.0023/2019/A and SKLQRCM(UM)-2020-2022,China);National Key Research and Development Program of China(Grant No.2017YFE0191500);the Research Fund of the University of Macao,Macao S.A.R.(Grant No.MYRG2019-00143-ICMS,China)
Inflammatory bowel disease(IBD)is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization.With no curative therapy for IBD at present,the development of effective therapeutics...
关键词：Receptor-mediated target Inflammatory bowel disease Crohn’s disease Ulcerative colitis Drug delivery Cell adhesion molecule Active target Targeted therapy 
Calcium channels at the center of nucleotide-binding leucine-rich repeat receptor-mediated plant immunity被引量：2
《Journal of Genetics and Genomics》2021年第6期429-432,共4页Shitou Xia Xueru Liu Yuelin Zhang 
the financial support to S.X.from the National Natural Science Foundation of China(31971836);the Hunan provincial Natural Science Foundation(2019JJ40126);the financial support to Y.Z.from NSERC Discovery grant program。
Higher plants utilize a variety of immune receptors to recognize pathogens and trigger defense responses.Intracellular nucleotidebinding leucine-rich repeat receptors(NLRs)are widely used for detecting pathogen effect...
关键词：Plant immunity NLR Gslcium channel 
Regulation of RIG-I-like receptor-mediated signaling:interaction between host and viral factors被引量：18
《Cellular & Molecular Immunology》2021年第3期539-555,共17页Koji Onomoto Kazuhide Onoguchi Mitsutoshi Yoneyama 
supported by Grants-in-Aids for Scientific Research(B)(18H02660)and(Q(19K07589 and 20K07534)from the Ministry of Education,Culture,Sports,Science,and Technology of Japan。
Retinoic acid-inducible gene I(RIG-l)-like receptors(RLRs)are RNA sensor molecules that play essential roles in innate antiviral immunity.Among the three RLRs encoded by the human genome,RIG-1 and melanoma differentia...
关键词：RIG-I-like receptors Viral infection Innate immunity Stress response 
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut被引量：4
《Gastroenterology Report》2019年第5期312-321,I0001,共11页Tian-Hang Li Ling Liu Ya-Yi Hou Su-Nan Shen Ting-Ting Wang 
This work is supported by grants from the National Natural Science Foundation of China(81572354 and 81772542 to T.W.);the Natural Science Foundation of Jiangsu Province in China(BK20161400 to T.W.).
C-type lectin receptors(CLRs)are powerful pattern-recognition receptors that discern‘self’and‘non-self’in our body and protect us from invasive pathogens by mediating immune recognition and response.The gastrointe...
关键词：C-type lectin receptors(CLRs) MICROBIOTA IMMUNITY inflammatory bowel disease(IBD) 
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