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作品数：69被引量：233H指数：8
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  • 期刊=Signal Transduction and Targeted Therapyx
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FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth被引量：6
《Signal Transduction and Targeted Therapy》2023年第6期3123-3143,共21页Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee 
supported by National Key R&D Program of China(2020YFA0803300),the Basic and Applied Basic Research Program of Guangzhou City(202102020084);the Basic and Applied Basic Research Program of Guangdong Province(2023A1515030245),the Natural Science Foundation of Guangdong Province(2021A1515012081);the National Natural Science Foundation of China(81630072);the Guangzhou Science and Technology Program Project(202206010167).
Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FB...
关键词：FBXW7 SUSTAINED FASN 
Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-lc/FASN axis被引量：8
《Signal Transduction and Targeted Therapy》2021年第4期1092-1094,共3页Jun Deng Mei Peng Sichun Zhou Di Xiao Xin Hu Simeng Xu Jingtao Wu Xiaoping Yang 
This research was funded by National Natural Science Foundation of China(81703008,81874212);Opening Fund for Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University),Ministry of Education(P201905);Huxiang High-Level Talent Innovation Team(2018RS3072);Major Scientific and Technological Projects for Collaborative Prevention and Control of Birth Defect in Hunan Province(2019SK1012);Key Grant of Research and Development in Hunan Province(2020DK2002).
Dear Editor,Metformin,a widely prescribed drug for treating typeⅡdiabetes,has shown an important anti-cancer property.1 However,new launched clinical trials did not achieve such desirable results.2 One explanation co...
关键词：BLADDER cancer CLUSTERIN 
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