PLACEBO-CONTROLLED

作品数：122被引量：659H指数：15
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  • 期刊=Signal Transduction and Targeted Therapyx
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Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial被引量：15
《Signal Transduction and Targeted Therapy》2022年第4期1194-1201,共8页Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li 
National Natural Science Foundation of China(U1903210,31530020,81701598,31570880,81471601,81801617);Beijing SciTech Program(Z171100000417007,Z191100006619114);Macao Science and Technology Fund(0094/2018/A3).
Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a ther...
关键词：PATIENTS PLACEBO METHOTREXATE 
Safety and immunogenicity of a recombinant COVID-19 vaccine(Sf9 cells)in healthy population aged 18 years or older:two single-center,randomised,double-blind,placebo-controlled,phase 1 and phase 2 trials被引量：5
《Signal Transduction and Targeted Therapy》2021年第8期2550-2560,共11页Fan-Yue Meng Fan Gao Si-Yue Jia Xiang-Hong Wu Jing-Xin Li Xi-Ling Guo Jia-Lu Zhang Bo-Pei Cui Zhi-Ming Wu Ming-Wei Wei Zhi-Long Ma Hai-Lin Peng Hong-Xing Pan Lin Fan Jing Zhang Jiu-Qin Wan Zhong-Kui Zhu Xue-Wen Wang Feng-Cai Zhu 
Phase I/II Clinical Trial and sample preparation of Recombinant COVID-19 Vaccine(Sf9 cells)(2020YFS0577);Development of a Prophylactic COVID-19 Vaccine(2020YFC0860200).
COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient supply.We did two singlecenter,randomised,double-blind,placebo-controlled phase 1 and phase 2 trials to assess the safe...
关键词：fatigue PHASE double 
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial被引量：22
《Signal Transduction and Targeted Therapy》2021年第3期888-896,共9页Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang 
Funded by The National Key R&D Program of China and others.ClinicalTrials.gov number,NCT04288102;supported by The National Key R&D Program of China(2020YFC0841900,2020YFC0844000,2020YFC08860900);The Innovation Groups of the National Natural Science Foundation of China(81721002);The National Science and Technology Major Project(2017YFA0105703).
Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patien...
关键词：damage PATIENTS double 
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