Project supported by the National Basic Research Program of China(G2002CB713808);the National Natural Science Foundation of China(№30270436 and 30470547);by the Outstanding Cross-century Faculty Grant from the Ministry of Education of China.
Aim: N-methyl-D-aspartate receptors (NMDAR) are heteromeric complexes primarily assembled from NR1 and NR2 subunits. In normal conditions, NR2 subunits assemble into homodimers in the endoplasmic reticulum (ER). ...