云南高校图书馆联盟文献共享服务平台- PHORBOL

PHORBOL: 作品数：25被引量：34H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：宋少伟高兴华葛春林孟凡斌郭克建更多>>; 相关机构：中国医科大学附属第一医院湖南医科大学浙江省医学科学院更多>>; 相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Science China Chemistry》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金沈阳市科技计划项目辽宁省教育厅科学基金国家重点基础研究发展计划更多>>

Seco-cyclic phorbol derivatives and their anti-HIV-1 activities: 《Chinese Journal of Natural Medicines》2024年第4期365-374,共10页HUANG Xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng WANG Haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian; supported by the National Natural Science Foundation of China(Nos.81202882 and 82060670);the Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022);the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD);Project of Innovative Research Team of Yunnan Province(No.202005AE160005)。; Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at po...; 关键词：seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring ESTERIFICATION Anti-HIV-1 agent

Synthesis and anti-HIV activities of phorbol derivatives: 《Chinese Journal of Natural Medicines》2024年第2期146-160,共15页HUANG Xiaolei TANG Chengrun HUANG Xusheng YANG Yun LI Qirun MA Mengdi ZHAO Lei YANG Liumeng CUI Yadong ZHANG Zhenqing ZHENG Yongtang ZHANG Jian; supported by the National Natural Science Foundation of China(Nos.81202882,82060670);Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022);the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD);and the Project of Innovative Research Team of Yunnan Province(No.202005AE160005).; In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-dec...; 关键词：Phorbol esters Anti-HIV-1 activity Syncytia formation 12-(Trans-4-fluorocinnamoyl)-13-decanoyl phorbol Safety index HIV-1 entry inhibitor HIV-1 reverse transcriptase inhibitor PKC activator

Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells被引量：3: 《Genes & Diseases》2019年第2期159-166,共8页R.L.Babu M.Naveen Kumar Rajeshwari H.Patil K.M.Kiran Kumar K.S.Devaraju Govindarajan T.Ramesh S.Chidananda Sharma; Grants Commission(UGC),New Delhi for providing Major Research Project financial Grant(F.No.34-250/2008(SR))to SCS.; Activator protein-1(AP-1)transcription factor is a key component of many signal transduction pathways involved in the regulation of cellular processes and controls rapid responses of mammalian cells when exposed to th...; 关键词：AP-1 transcription factor Cell cycle FORSKOLIN MCF-7 cells Phorbol esters

Sustained small and intermediate size proteins expression in phorbol 12-myristate 13-acetate/ionomycine prolonged stimulated human fibroblasts: 《Asian Pacific Journal of Tropical Biomedicine》2017年第5期432-436,共5页Zeinab Abedian Sadegh Fattahi Roghayeh Pourbagher Sahar Edrisi Amrollah Mostafazadeh; Supported by the Research and Technology Council of Babol University of Medical Sciences with Grant No.9031029; Objective:To compare the protein profile of culture supernatants in stimulated and unstimulated human fibroblasts to find some proteins indicating the presence of fibroblasts and their activation status.Methods:Dermal...; 关键词：Fibroblast activation Apoptosis Protein electrophoresis phorbol 12-myristate 13-acetate Ionomycine Fibrosis Biomarker

Experimental study on the inhibitory effect of arsenic trioxide combined with phorbol ester on the proliferation of acute promyelocytic leukemia cell line Kasumi-1: 《Journal of Hainan Medical University》2017年第9期21-24,共4页Na Zhang Yong-Qian Jia Sheng-Lan Qing; Objective:To study the effect of arsenic trioxide (As2O3) combined with phorbol ester (PMA) on the proliferation of acute promyelocytic leukemia cell line Kasumi-1.Methods:Acute promyelocytic leukemia cell lines Kasum...; 关键词：Acute PROMYELOCYTIC LEUKEMIA Arsenic TRIOXIDE PHORBOL ester PROLIFERATION

PMA及IL4序贯诱导人单核细胞系成为M2型巨噬细胞被引量：2: 《解剖科学进展》2015年第3期294-298,共5页孟凡斌葛春林郭克建宋少伟高兴华; 国家自然科学基金(No.81301767);辽宁省高等学校重大科技平台免疫皮肤病重点实验室自主创新课题基金;辽宁省教育厅项目(No.L2014294);沈阳市科技计划项目(No.F15-199-1-42); 目的将人单核细胞系U937及THP-1体外诱导得到M2型巨噬细胞。方法将U937及THP-1细胞以phorbol 12-Myristate 13-Acetate(PMA)及白介素-4(interleukin,IL-4)序贯诱导,采用q RT-PCR法及ELISA法检测M1/M2标志物m RNA及蛋白表达。结果 PMA使...; 关键词：人单核细胞巨噬细胞 PHORBOL 12-Myristate 13-Acetate 白介素-4 雷帕霉素

Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII- MDR1 and Caco.2 cell monolayer models被引量：4: 《Acta Pharmacologica Sinica》2014年第2期283-291,共9页Yu-hua LI Hui-chang BI Ling HUANG Jing JIN Guo-ping ZHONG Xu-nian ZHOU Min HUANG; Aim： To investigate the effects of phorbol 12-myristate 13-acetate （PMA）, a PKC activator, on P-glycoprotein-mediated efflux of digoxin in two cell transport models. Methods： Caco-2 cells, wild MDCKII cells （MDCK...; 关键词：drug-drug interaction membrane transporter P-GLYCOPROTEIN MDR1 Caco-2 cells DIGOXIN phorbol ester PKC VERAPAMIL

Relaxin Inhibit Cardiac Fibrosis Induced by Phorbol 12-myristate 13-acetate: 《Biomedical and Environmental Sciences》2014年第2期138-141,共4页WANG Yu Peng WANG Ping DONG Lei CHEN Hui WU Yong Quan LI Hong Wei LI Min; This work was supported by the National Natural Science Foundation of China(Grant NoS.81100169).; Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate （PMA, PKC activator） on cardiac fibrosis. So the influence of relaxi...; 关键词：PKC Figure PMA Relaxin Inhibit Cardiac Fibrosis Induced by Phorbol 12-myristate 13-acetate

In Vivo Anti-Inflammatory Assessment of Quillaja saponaria Mol. Extracts: 《Journal of Life Sciences》2013年第12期1243-1248,共6页Mait6 Rodriguez-Diaz Olosmira Correa Carlos Cartagen Bruce K. Cassels CarlaDelporte; Aqueous extracts from the native Chilean Quillaja saponaria tree are used orally and topically to treat lung inflammatory problems and toothache. This study aimed to corroborate their presumed anti-inflammatory activi...; 关键词：Quillaja saponaria TRITERPENOIDS quillaic acid phytolaccagenic acid topical anti-inflammatory activity phorbol acetate arachidonic acid.

Two potentially specific but relevant patterns of proteomic change Response of SH-SY5Y cells to differentiation with retinoic acid followed by phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate, and susceptibility of differentiated cells to dopamine: 《Neural Regeneration Research》2010年第20期1525-1533,共9页Mingxiu Tian Xing'an Li Ming Chang Yingjiu Zhang Danping Wang Hongrong Xie Linsen Hu; the Science and Technology Development Program of Jilin Province, No. 200505200;the Distinguished Professor Foundation of Jilin University, No. 450011011204; Dopamine （DA） exposure at a dose of 100 pmol/L for 24 hours causes oxidative stress in SH-SY5Y cells with induction of neuronal differentiation by retinoic acid （RA,10 pmol/L,72 hours） followed by phorbol ester 12...; 关键词：SH-SY5Y cells retinoic acid phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate DOPAMINE proteomic analysis Parkinson＇s disease neural regeneration

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