To editor:The use of digoxin for the transplacental treatment of sustained fetal tachyarrhythmia(FT)was first reported in 1980.1 This medication is the first-line and most common antiarrhythmic in nonhydropic fetuses....
Supported by NIH UO1(to Mehal WZ),No.5U01AA026962-02.
Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several ye...
BACKGROUND Cardiac and hepatic functionality are intertwined in a multifaceted relationship.Pathologic processes involving one may affect the other through a variety of mechanisms,including hemodynamic and membrane tr...
The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is ...
supported by Grants from the National Natural Science Foundation of China(81873749 and 81801072)。
The glymphatic system plays a pivotal role in maintaining cerebral homeostasis.Chronic cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately m...
BACKGROUND The association between digoxin and mortality is an unclear issue.In older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is scarce.Our aim is to assess th...
supported by National Natural Science Foundation of China(No.81773656);Liaoning Revitalization Talents Program(No.XLYC1808017,China);Shenyang Youth Science and Technology Innovation Talents Program(No.RC190454,China)。
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death.Moreover,circulating tumor cell(CTC)clusters play a pivotal role in tumor metastasis.Herein,we develop cancer-specific calcium nano...
supported by the Science&Technology Development Fund of Tianjin Education Commission for Higher Education[2017KJ230].
Background Colorectal cancer(CRC)is one of the leading causes of cancer death worldwide.Novel drugs for CRC therapy are urgently needed.Digoxin has been in clinical use for treatment of heart failure and atrial arrhyt...
Objective To investigate the effects and mechanism of digoxin on atrium electrical remodeling and susceptibility of atrial fibrillation(AF)in aged rabbits.Methods Twenty aged male New Zealand rabbits were divided into...
Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In additio...