DIGOXIN

作品数:48被引量:68H指数:4
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相关领域:医药卫生更多>>
相关作者:杨浩柯永胜刘宝洪朱宾顺何云南更多>>
相关机构:湖州市第一人民医院皖南医学院弋矶山医院内蒙古科慧生物科技有限责任公司中国人民解放军更多>>
相关期刊:《中华临床医药杂志(北京)》《Chinese Medical Journal》《World Journal of Cardiology》《Cardiovascular Innovations and Applications》更多>>
相关基金:国家自然科学基金更多>>
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Digoxin for Fetal Tachyarrhythmia:Toxicity in an Underweight Mother
《Maternal-Fetal Medicine》2024年第4期262-264,共3页Jian Lynn Lee Hannah Abdul Halim Amelia Alias Pavithira Subramaniam Buvanes Chelliah 
To editor:The use of digoxin for the transplacental treatment of sustained fetal tachyarrhythmia(FT)was first reported in 1980.1 This medication is the first-line and most common antiarrhythmic in nonhydropic fetuses....
关键词:DIGOXIN Fetal tachyarrhythmia Therapeutic drug monitoring 
New uses for an old remedy:Digoxin as a potential treatment for steatohepatitis and other disorders
《World Journal of Gastroenterology》2023年第12期1824-1837,共14页Fatima Jamshed Farzaneh Dashti Xinshou Ouyang Wajahat Z Mehal Bubu A Banini 
Supported by NIH UO1(to Mehal WZ),No.5U01AA026962-02.
Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several ye...
关键词:DIGOXIN Cardiac glycosides Oxidative stress Nonalcoholic steatohepatitis Alcohol-associated steatohepatitis Sterile inflammation 
Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance
《World Journal of Gastrointestinal Pathophysiology》2022年第3期73-84,共12页Parker Giroux Patrick B Kyle Chalet Tan Joseph D Edwards Michael J Nowicki Hua Liu 
BACKGROUND Cardiac and hepatic functionality are intertwined in a multifaceted relationship.Pathologic processes involving one may affect the other through a variety of mechanisms,including hemodynamic and membrane tr...
关键词:CHOLESTASIS Digoxin clearance Organic anion transporting polypeptides P-glycoproteins/multidrug resistance 1 Bile duct ligation 
The Presence of Phases and the Inability of the Classical Compartment Models to Provide Pharmacokinetic Parameters of Physiological Significance for Lipophilic Drugs
《Journal of Biosciences and Medicines》2022年第4期1-13,共13页Michalakis Savva 
The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is ...
关键词:Lipophilic Drugs Pharmacokinetic Compartment Model Apparent Volume of Distribution Clearance PRAZOSIN DOXAZOSIN DIGOXIN PINDOLOL 
Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion被引量:8
《Neuroscience Bulletin》2022年第2期181-199,共19页Jie Cao Di Yao Rong Li Xuequn Guo Jiahuan Hao Minjie Xie Jia Li Dengji Pan Xiang Luo Zhiyuan Yu Minghuan Wang Wei Wang 
supported by Grants from the National Natural Science Foundation of China(81873749 and 81801072)。
The glymphatic system plays a pivotal role in maintaining cerebral homeostasis.Chronic cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately m...
关键词:Chronic cerebral hypoperfusion Cognitive impairment DIGOXIN Glymphatic system White matter injury 
Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish Multicenter Registry被引量:1
《Journal of Geriatric Cardiology》2021年第10期809-815,共7页Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubelos-Fernández Álvaro López-Masjuán Ríos María Melendo-Viu AndrésÍñiguez-Romo 
BACKGROUND The association between digoxin and mortality is an unclear issue.In older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is scarce.Our aim is to assess th...
关键词:PATIENTS DIGOXIN FIBRILLATION 
Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy被引量:2
《Acta Pharmaceutica Sinica B》2021年第10期3262-3271,共10页Dan Li Yingli Wang Chang Li Qiu Wang Bingjun Sun Haotian Zhang Zhonggui He Jin Sun 
supported by National Natural Science Foundation of China(No.81773656);Liaoning Revitalization Talents Program(No.XLYC1808017,China);Shenyang Youth Science and Technology Innovation Talents Program(No.RC190454,China)。
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death.Moreover,circulating tumor cell(CTC)clusters play a pivotal role in tumor metastasis.Herein,we develop cancer-specific calcium nano...
关键词:Cell-cell junctions DIGOXIN DOXORUBICIN Homologous targeting Circulating tumor cell clusters Epithelial-mesenchymal transition Breast cancer Lung metastasis 
Multifaceted anti-colorectal tumor effect of digoxin on HCT8 and SW620 cells in vitro
《Gastroenterology Report》2020年第6期465-475,I0002,共12页Yong-Qiang Hou Ying-Ying Wang Xing-Can Wang Yao Liu Chun-Ze Zhang Zhe-Sheng Chen Zhe Zhang Wei Wang De-Xin Kong 
supported by the Science&Technology Development Fund of Tianjin Education Commission for Higher Education[2017KJ230].
Background Colorectal cancer(CRC)is one of the leading causes of cancer death worldwide.Novel drugs for CRC therapy are urgently needed.Digoxin has been in clinical use for treatment of heart failure and atrial arrhyt...
关键词:DIGOXIN ANTITUMOR colorectal cancer cell-cycle arrest METASTASIS multidrug resistance 
Effects and mechanism of digoxin on atrium electrical remodeling and susceptibility of atrial fibrillation in aged rabbits
《China Medical Abstracts(Internal Medicine)》2019年第4期212-212,共1页WANG Teng 
Objective To investigate the effects and mechanism of digoxin on atrium electrical remodeling and susceptibility of atrial fibrillation(AF)in aged rabbits.Methods Twenty aged male New Zealand rabbits were divided into...
关键词:EFFECTS MECHANISM DIGOXIN 
Antiarrhythmic drug usage and prostate cancer: a population-based cohort study
《Asian Journal of Andrology》2018年第1期37-42,共6页Li-Ting Kao Chung-Chien Huang Herng-Ching Lin Chao-Yuan Huan 
Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In additio...
关键词:antiarrhythmic drugs CANCER DIGOXIN ion channel blocker prostate cancer 
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