New uses for an old remedy:Digoxin as a potential treatment for steatohepatitis and other disorders  

作　　者：Fatima Jamshed Farzaneh Dashti Xinshou Ouyang Wajahat Z Mehal Bubu A Banini 

机构地区：[1]Section of Digestive Diseases,Yale School of Medicine,New Haven,CT 06510,United States [2]Griffin Hospital-Yale University,Derby,CT 06418,United States [3]West Haven Veterans Medical Center,West Haven,CT 06516,United States

出　　处：《World Journal of Gastroenterology》2023年第12期1824-1837,共14页世界胃肠病学杂志（英文版）

基　　金：Supported by NIH UO1(to Mehal WZ),No.5U01AA026962-02.

摘　　要：Repurposing of the widely available and relatively cheap generic cardiac glycoside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases.Over the past several years,there have been significant advances in the study of digoxin pharmacology and its potential noncardiac clinical applications,including anti-inflammatory,antineoplastic,metabolic,and antimicrobial use.Digoxin holds promise in the treatment of gastrointestinal disease,including nonalcoholic steatohepatitis and alcoholassociated steatohepatitis as well as in obesity,cancer,and treatment of viral infections,among other conditions.In this review,we provide a summary of the clinical uses of digoxin to date and discuss recent research on its emerging applications.

关 键 词：DIGOXIN Cardiac glycosides Oxidative stress Nonalcoholic steatohepatitis Alcohol-associated steatohepatitis Sterile inflammation 

分 类 号：R575[医药卫生—消化系统]