云南高校图书馆联盟文献共享服务平台- DOXAZOSIN

DOXAZOSIN: 作品数：16被引量：24H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张燕高红雨舒畅史燕涛董占宇更多>>; 相关机构：上海交通大学河北省保定市第一医院北京师范大学克诺尔有限公司更多>>; 相关期刊：《山西医药杂志》《Asian Journal of Andrology》《中外健康文摘》《Journal of Biosciences and Medicines》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家杰出青年科学基金更多>>

The Presence of Phases and the Inability of the Classical Compartment Models to Provide Pharmacokinetic Parameters of Physiological Significance for Lipophilic Drugs: 《Journal of Biosciences and Medicines》2022年第4期1-13,共13页Michalakis Savva; The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is ...; 关键词：Lipophilic Drugs Pharmacokinetic Compartment Model Apparent Volume of Distribution Clearance PRAZOSIN DOXAZOSIN DIGOXIN PINDOLOL

多沙唑嗪对兔动脉粥样硬化斑块及炎症因子表达的影响: 《山西医药杂志》2015年第14期1617-1618,共2页赵静惠张燕靳翠彬高红雨; 多沙唑嗪（doxazosin ，DOX）在国外已广泛用于治疗良性前列腺增生和高血压病，近年来越来越多的实验表明DOX具有改善脂代谢作用，并可通过改善血管内皮功能、抑制血管平滑肌细胞增殖、减少血小板凝聚率等环节延缓动脉粥样硬化（AS）进...; 关键词：动脉粥样硬化斑块多沙唑嗪因子表达抑制血管平滑肌细胞增殖 DOXAZOSIN 良性前列腺增生细胞黏附因子1 肿瘤坏死因子α

Co-Localization of Alpha1-Adrenoceptors and GPR55: A Novel Prostate Cancer Paradigm?: 《Pharmacology & Pharmacy》2015年第4期212-220,共9页Kalyani Chimajirao Patil Laura McPherson Craig James Daly; α1-adrenoceptors (α1-ARs) and “cannabinoid-like” G Protein Coupled Receptor 55 (GPR55) belong to the G-protein coupled receptor (GPCR) family and play a crucial role in regulating prostate function. Although physi...; 关键词：PROSTATE Α1-ADRENOCEPTOR GPR55 DOXAZOSIN

Effect of Longbishu Capsule (癃闭舒胶囊) plus Doxazosin on Benign Prostatic Hyperplasia:A Randomized Controlled Trial被引量：3: 《Chinese Journal of Integrative Medicine》2014年第11期818-822,共5页宋春生郭军常德贵陈磊张瑞赵家有王福张强; Supported by the Project of Science Research for the 11th FiveYear Plan(No.2007BAI20B044); Objective：To investigate the effect of Longbishu Capsule（癃闭舒胶囊,LBS）,doxazosin,and combination therapy on benign prostatic hyperplasia（BPH）.Methods：A randomized,double-blind,multi-center parallel trial was c...; 关键词：benign prostatic hyperplasia combination therapy Longbishu Capsule doxazosin clinical progression Chinese medicine

（-）Doxazosin is a necessary component for the hypotensive effect of （±）doxazosin during long-term administration in conscious rats被引量：4: 《Acta Pharmacologica Sinica》2014年第1期48-57,共10页Jing ZHAO De-zhi KONG Qing LI Ya-qin ZHEN Miao WANG Yan ZHAO Dong-kai WANG Lei-ming REN; Aim： Doxazosin is a racemic mixture of （–）doxazosin and （＋）doxazosin that is currently used as an add-on therapy for hypertension. In this study we investigated the contribution of each enantiomer to the hypot...; 关键词：DOXAZOSIN ENANTIOMER blood pressure HYPOTENSION plasma drug concentration Α1-ADRENOCEPTOR NORADRENALINE tail artery conscious rat

Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro被引量：2: 《Acta Pharmacologica Sinica》2013年第12期1568-1574,共7页Jia-an SUN De-zhi KONG Ya-qin ZHEN Qing LI Wei ZHANG Jiang-hua ZHANG Zhi-wei YIN Lei-ming REN; Aim：（＋）Doxazosin is a long-lasting inhibitor of a1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective bindi...; 关键词：DOXAZOSIN ENANTIOMER STEREOSELECTIVITY plasma protein binding equilibrium dialysis species difference pharmacokinetics benign prostatic hyperplasia lower urinary tract symptom al-adrenoceptor

Effect of doxazosin on rabbit bladder compliance after partial bladder outlet obstruction: 《外科研究与新技术》2011年第4期243-244,共2页皇甫雪军; Objective To explore the effect of doxazosin on rabbit bladder compliance after partial bladder outlet ob- struction. Methods A total of 40 male New Zealand white rabbits were randomized into 4 groups,with 10 rabbits ...; 关键词：Effect of doxazosin on rabbit bladder compliance after partial bladder outlet obstruction der

An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction, and lower urinary tract symptoms secondary to benign prostatic hyperplasia被引量：2: 《Asian Journal of Andrology》2011年第4期630-635,共6页Zhe Jin Zhi-Chao Zhang Ji-Hong Liu Jun Lu Yu-Xin Tang Xiang-Zhou Sun Wei-Dong Song Bing Gao Ying-Lu Guo Zhong-Cheng Xin; This study sought to investigate the clinical efficacy and safety of combined oral therapy with sildenafil and doxazosin GITS compared to sildenafil monotherapy in treating Chinese patients with erectile dysfunction ...; 关键词：doxazosin GITS erectile dysfunction IPSS lower urinary tract symptoms quality of life sildenaf

多沙唑嗪（Doxazosin）治疗良性前列腺增生的临床观察: 《中外健康文摘》2009年第02X期54-55,共2页史燕涛舒畅董占宇; 目的观察多沙唑嗪治疗良性前列腺增生的效果。方法将130例良性前列腺增生患者服用多沙唑嗪前后IPSS、前列腺体积V、最大尿流率、残余尿量四项指标进行对比。结果用药5个月、1年、3年后上述四项指标均明显改善。结论多沙唑嗪对良性前列...; 关键词：良性前列腺增生多沙唑嗪治疗作用临床观察前列腺体积最大尿流率 IPSS 残余尿量

Involvement of transcription factor activator protein-2α in doxazosin-induced HeLa cell apoptosis被引量：2: 《Acta Pharmacologica Sinica》2008年第4期465-472,共8页Lu GAY Dong-xing ZHU Li-ping YANG Ru-shi LIU Feng YAN Jian ZHANG; This work was supported in part by the 973 project of the Ministry of Science and Technique of China （№ 2005CB522505 and 2006CBOF0306）, the National Natural Science Foundation of China （№ 20335020 and 30470945）, the Program for Changjiang Scholars and Innovative Research Team in University （№ IRT0445）, and the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China （№ 705041）.; Aim： To investigate the pro-apoptotic effects of α- 1-adrenergic inhibitor doxazosin in HeLa cells and the potential involvement of transcription factor activator protein-2α （AP-2α） in doxazosin-induced apoptosi...; 关键词：activator protein-2α or-1-adrenergic inhibitor APOPTOSIS caspases cervical cancer DOXAZOSIN HeLa cells transcription factors

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