The Presence of Phases and the Inability of the Classical Compartment Models to Provide Pharmacokinetic Parameters of Physiological Significance for Lipophilic Drugs  

作　　者：Michalakis Savva Michalakis Savva(South University, Savannah, USA)

机构地区：[1]South University, Savannah, USA

出　　处：《Journal of Biosciences and Medicines》2022年第4期1-13,共13页生物科学与医学（英文）

摘　　要：The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is used to explain the unusually large compartment volumes and apparent volumes of distribution of lipophilic drugs, as well as to identify which of the pharmacokinetic parameters of the classical compartment models are biologically relevant.The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is used to explain the unusually large compartment volumes and apparent volumes of distribution of lipophilic drugs, as well as to identify which of the pharmacokinetic parameters of the classical compartment models are biologically relevant.

关 键 词：Lipophilic Drugs Pharmacokinetic Compartment Model Apparent Volume of Distribution Clearance PRAZOSIN DOXAZOSIN DIGOXIN PINDOLOL 

分 类 号：O62[理学—有机化学]