supported by the National Natural Science Foundation of China (81930121,82125008 to Y.C.C.);National Key Research and Development Program of China (2018YFA0107902 to Y.C.C.and 2018YFA0801403 to Z.B.W.);Major Basic Research Project of Science and Technology of Yunnan (202001BC070001 to Y.C.C.);Natural Science Foundation of Yunnan Province (202102AA100053 to Y.C.C.)。
Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube closure.Although folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often...