finically supported by the NSF of China(81773687,81922070,81973286,81703604);the National Key Research and Development Program of China(2017YFC1700200,2017YFC1702000);the Open Project Program of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica(No.JKLPSE-201803);the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Program of Shanghai Academic/Technology Research Leader(18XD1403600);Drug Innovation Major Project(2018ZX09731016);Shuguang Program(18SG40)supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission;the Graduate Innovation Project of Shanghai University of Traditional Chinese Medicine(Y2019063)。
The human UDP-glucuronosyltransferase 1A1(UGT1A1),one of the most essential conjugative enzymes,is responsible for the metabolism and detoxification of bilirubin and other endogenous substances,as well as many differe...