supported by the National Natural Science Foundation of China(21420102002,21771109,21731004,21807060,22077066 and 22025701);the China Postdoctoral Science Foundation(2019M651874)。
Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies.To exploit the synthetic lethality concept in the design of chemical anti-cancer age...