METALLODRUGS

作品数：2被引量：2H指数：1
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相关领域：医药卫生更多>>
相关期刊：《National Science Review》《Cancer Drug Resistance》更多>>
相关基金：中国博士后科学基金国家自然科学基金更多>>
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Auranofin and its analogs as prospective agents for the treatment of colorectal cancer被引量：1
《Cancer Drug Resistance》2022年第1期1-14,共14页Lara Massai Damiano Cirri Tiziano Marzo Luigi Messori 
funding the project“Advanced mass spectrometry tools for cancer research:novel applications in proteomics,metabolomics and nanomedicine”(Multi-user Equipment Program 2016,Ref.code 19650);the Beneficentia Stiftung,Vaduz(BEN2019/48 and University of Pisa(Rating Ateneo 2019-2020)for the financial support;supported by the University of Pisa under the“PRA-Progetti di Ricerca di Ateneo”Institutional Research Grants-Project no.PRA_2020_58“Agenti innovativi e nanosistemi per target molecolari nell’ambito dell’oncologia di precisione”to Marzo T;the financial support(two-year fellowship for Italy“Marcello e Rosina Soru”-Project Code:23852).
Today colorectal cancer(CRC)is one of the leading causes of cancer death worldwide.This disease is poorly chemo-sensitive toward the existing medical treatments so that new and more effective therapeutic agents are ur...
关键词：AURANOFIN CRC colorectal cancer METALLODRUGS anticancer agents GOLD gold-based drugs 
Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo被引量：1
《National Science Review》2021年第9期45-54,共10页Xuling Xue Chenggen Qian Qin Tao Yuanxin Dai Mengdi Lv Jingwen Dong Zhi Su Yong Qian Jing Zhao Hong-Ke Liu Zijian Guo 
supported by the National Natural Science Foundation of China(21420102002,21771109,21731004,21807060,22077066 and 22025701);the China Postdoctoral Science Foundation(2019M651874)。
Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies.To exploit the synthetic lethality concept in the design of chemical anti-cancer age...
关键词：metallodrug cancer therapy mitochondrial targeting bio-orthogonally catalyzed lethality bio-orthogonal reaction 
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