supported by the National Key R&D Program of China(2017YFA0505500);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13040700);the National Natural Science Foundation of China(61403363,91529303,31771476,81471047);the Key Project of Natural Science of Anhui Provincial Education Department(KJ2016A002);supported by JSPS KAKENHI(15H05707);JST CREST(JPMJCR14D2),Japan
A new model-free method has been developed and termed the landscape dynamic network biomarker(l-DNB) methodology. The method is based on bifurcation theory, which can identify tipping points prior to serious disease d...