Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Defining the minimum substrate and charge recognition model of gamma-secretase
《Acta Pharmacologica Sinica》2017年第10期1412-1424,共13页Yan YAN Ting-Hai XU Karsten MELCHER H Eric XU 
γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can oligomerize and aggregate to form amyloid plaque...
关键词：Alzheimer＇s disease amyloid beta （Aβ） amyloid precursor protein （APP） C99  γ-secretase minimum substrate Notchprotein recognition model 
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis被引量：14
《Cell Research》2010年第2期138-153,共16页Lin Teng Jian Zhao Feifei Wang Lan Ma Gang Pei 
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Dr David Westaway （University of Alberta） for TgCRND8 mice, Dr David Baltimore （California Institute of Technology） for lentiviral constructs, Dr Raphael Kopan （Washington University） for the plasmid of myc-tagged NotchAE and Dr Johan Lundkvist （Karolinska Institutet） for the plasmid of Gal4-driven luciferase reporter gene, the plasmid of APP/CTFI3-GVP and NAE-GVP. We appreciate Shunmei Xin, Shan Chen and Xianglu Zeng for their technical assistance. We thank all members of the lab for sharing reagents and advice. This research was supported by the Ministry of Science and Technology （2009ZX09103-684）, the National Natural Science Foundation of China （30621091, 30625014, 30623003, 30871285 and 90713047）, the Shanghai Municipal Commission for Science and Technology （07PJ14099 and 09JC1416400）, and the Chinese Academy of Sciences （2007KIP204）.
Dysregulation of β-site APP-cleaving enzyme （BACE） and/or γ-secretase leads to anomalous production of amyloid-β peptide （Aβ） and contributes to the etiology of Alzheimer＇s disease （AD）. Since these secreta...
关键词：G protein-coupled receptor Alzheimer＇s disease BACE Γ-SECRETASE Notch 
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