the National Key Research and Development Program [2016YFA0502304 to H.L.];the National Natural Science Foundation of China (grant 81825020 to H.L., 81803437 to S.L.);the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China (No. 2018ZX09711002);Shanghai Sailing Program (No. 18YF1405100);National Program for Special Supports of Eminent Professionals and National Program for Support of Top-notch Young Professionals.
Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and va...