supported by the Ministry of Science and Technology of China(2020YFA0803400/2020YFA0803402 and 2019YFA0801703);the National Natural Science Foundation of China(81790250/81790253,9195920,8187224,81872240,81802745 and 82002951);the Innovation Program of the Shanghai Municipal Education Commission(N173606);the China Postdoctoral Science Foundation(2021M690676)。
BCAT2-mediated branched-chain amino acid(BCAA)catabolism is critical for pancreatic ductal adenocarcinoma(PDAC)development,especially at an early stage.However,whether a high-BCAA diet promotes PDAC development in viv...