supported by the National Key Research and Development Program(2022YFC2503400);the Fundamental Research Funds for the Central Universities(2019PT350005);the National Natural Science Foundation of China(81970444);the Beijing Municipal Science and Technology Project(Z201100005420030);the National High Level Talents Special Support Plan(2020-RSW02);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-065);the Sanming Project of Medicine in Shenzhen(SZSM202011013)。