supported by the Ministry of Science and Technology of China(2018YFA0703200 and 2022YFB3603800);the National Natural Science Foundation of China(21875259,52233010,51725304,61890943 and 22021002);the Chinese Academy of Sciences Project for Young Scientists in Basic Research(YSBR-053);the Youth Innovation Promotion Association of the Chinese Academy of Sciences;the National Program for Support of Top-notch Young Professionals;Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202012);the Key Research Program of the Chinese Academy of Sciences(XDPB13)。