突变小鼠

作品数:56被引量:68H指数:5
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相关领域:生物学更多>>
相关作者:王冬平李善如仇志华谢晓丽吴晓明更多>>
相关机构:复旦大学宁波美丽人生医药生物科技发展有限公司浙江大学南京大学更多>>
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相关基金:国家自然科学基金国家科技部专项基金协和青年科研基金上海市卫生局青年科研基金更多>>
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Abnormal gonad development in Kit^(W-2Bao) mice caused by a Kit gene missense mutation被引量:1
《Chinese Science Bulletin》2010年第36期4143-4149,共7页WU BaoJin YIN LiJing LU ZhengLan YIN YuShu YANG WeiWei YANG Rong KANG XiaoDong LIU GuiJie YIN HongPing YU LiPing Gu MeiEr WU PeiLin 
supported by the National Natural Science Foundation of China (30670231);the Zhejiang Science and Technology Project for Laboratory Animal (2009F80022)
KitW-2Bao mice are single-gene autosomal dominant mutation mice with a B6 background that were bred in our laboratory. Heterozygotes had morphological characteristics including albinism of the abdomen, extremities, an...
关键词:突变小鼠 结构异常 单基因 套件 性腺 原始生殖细胞 工具包 杂合子缺乏 
Mapping of genetic modifiers of Plcd1 in scant hair mice(snthr^(1Bao))
《Chinese Science Bulletin》2010年第35期4026-4031,共6页WU BaoJin ZENG YongMei MAO HuiHua YIN LiJing ZHU Jie YANG WeiWei YIN XiaoShu WU PeiLin ZHANG WeiDong 
supported by the National Natural Science Foundation of China (30670231 and 30400266);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China
The scant hair mutant mouse(locus symbol:snthr1Bao) is a recessive mutation that originated in an ethylnitrosourea chemical carcinogenesis study using the DBA/2J inbred strain.The gene responsible for the mutation was...
关键词:突变小鼠 遗传修饰 映射 QTL检测 基因符号 信号转导通路 基因分型 未成年人 
Mutations of nuclear localization signals in mNANOG generate dominant negative mutants
《Chinese Science Bulletin》2009年第8期1361-1368,共8页ZHANG Juan ZHANG XiaoFei PEI DuanQing 
Supported by National Natural Science Foundation of China (Grant Nos.30725012,30630039 and 90813033);Knowledge Innovation Project of Chinese Academy of Sciences (Grant No.KSCX2-YW-R-48);Guangzhou Science and Technology Commission Foundation (Grant No.2008A1-E4011);National Key Basic Research and Development Program of China (Grant Nos.2006CB701504,2006CB943600,2007CB948002 and 2007CB947804)
Mouse NANOG plays a critical role in maintaining self-renewal and pluripotency of embryonic stem cells.Yet,the precise mechanism of how mNANOG functions is still less known.Here,we report that mouse NANOG has two nucl...
关键词:核定位信号 突变体 显性 NANOG 突变小鼠 胚胎干细胞 转录活性 职能作用 
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