Supported by the National Natural Science Foundation of China(30973686);Medicinal Science and Techology Research Project(BWS11J052);the National key scientific instrument and equipment development project(2012YQ0401400901);the National Science and Techology Major Project(2012ZX09J12201);the National Key Technology R&D Program of China(2009BAK59B01);the Foundation of State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center(SMFA10B01,SMFA12B05)