This work was supported by the grants from the National Natural Science Foundation of China (30623003 and 81172449); National Basic Research Program of China (973 Program) (2010CB529901 and 2011CB510104);Important National Science & Technology Specific Project of Hepatitis and Hepatoma Related Program (2008ZX10002- 023); New Innovation Program (2009-ZX-09102-246);and Zhejiang Sci-Tech University grant (1016834-Y).
Interferon-β (IFN-β) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN-β (ZD55-IFN-β)...