Supported by National Natural Science Foundation of China,No.82303047,No.82372507,No.82172196 and No.32401046;Natural Science Foundation of Hunan Province,No.2022JJ40801。
Diabetic nephropathy(DN)is a well-known microvascular complication in patients with diabetes mellitus,which is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compart...
Supported by National Natural Science Foundation of China,No.82471616,No.82170418,and No.82271618;Natural Science Foundation of Hubei Province,No.2022CFA015;Central Guiding Local Science and Technology Development Project,No.2022BGE237;Key Research and Development Program of Hubei Province,No.2022BCE001,and No.2023BCB139;Hubei Provincial Health Commission Project,No.WJ2023M151。
We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising thera...
supported by grants from the National Natural Science Foundation of China[82070574,818004580];the Nature Science Foundation Team Project of Guangdong Province[2018B03031200].
Background:Intestinal barrier defect is an essential inflammatory bowel disease(IBD)pathogenesis.Mitochondrial dysfunction results in energy deficiency and oxidative stress,which contribute to the pathogenesis of IBD....
supported by Beijing Natural Science Foundation(7222253,China);National Natural Science Foundation of China(81973350/82173841);supported by Beijing Natural Science Foundation(7212149,China)。
Insulin-like growth factor-1 receptor(IGF-1R) has been made an attractive anticancer target due to its overexpression in cancers.However,targeting it has often produced the disappointing results as the role played by ...