supported by the Keio University Medical Science Fund(to YO);the General Insurance Association of Japan(to YK);the Takeda Science Foundation(to YK);grants from the Japan Agency for Medical Research and Development(AMED)(Grant JP24bm1123037 and JP24ym0126118)(to HO)。
Spinal cord injury(SCI)can cause motor and sensory paralysis,and autonomic nervous system disorders including malfunction of urination and defecation,thereby significantly impairing the quality of life.Researchers con...
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
supported by the BK21 FOUR(Fostering Outstanding Universities for Research);the Basic Science Research Program through the National Research Foundation of Korea(NRF);the Regional Innovation Mega Project Program through the Korea Innovation Foundation funded by the Ministry of Education(MOE);the Ministry of Science and ICT(MSIT)(NRF-2022R1A2C1004204,RS-2023-00219563,2023-DD-UP-0007);the Soonchunhyang University Research Fund(to KK)。
Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal cord.This leads to muscle weakness,paralysis,and ul...
supported by the Natural Science Foundation of Fujian Province,No.2020J02027;the National Natural Science Foundation of China,No.31970461;the Foundation of NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate,Fujian Maternity and Child Health Hospital,No.2022-NHP-05(all to WC).
Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in viv...
Axon disconnection in the central nervous system(CNS) usually causes signal transduction failure and severe functional deficits in patients with neurological disorders. Currently, there is no cure for patients with CN...
supported by FATALSDRUG Project(Progetti di Ricerca@CNR)from National Research Council,Italy(to CV)。
Amyotrophic lateral sclerosis(ALS)is classified as a multigenic,multifactorial,and heterogeneous neurodegenerative/neuroinflammatory disease that slays especially upper and lower motor neurons controlling voluntary mu...
Background:Failure of axon regeneration after spinal cord injury(SCI)underlies the paralysis that so profoundly affects patients’quality of life.Many factors are involved in the regeneration failure.Chondroitin sulfa...
supported by the National Institute of Health grants R01NS069726 and R01NS094539 to SD;the America Heart Association grants 16GRNT31280014 to SD.
Cerebral focal ischemic stroke(FIS)is a leading brain disorder associated with human debilitation and death.It is induced by the formation of a thrombus in the arteries that supply blood to the central nervous system....
supported by The John M.and Jocelyn H.K.Watkins Distinguished Chair in Cell Therapies(to DDP);The Miami Project to Cure Paralysis and The Buoniconti Fund(to DDP and MG)。
Multiple sclerosis(MS)is a neurological condition characterized by the disruption of the blood-brain barrier,immune system activation,and infla mmation that is accompanied by glial reactivity,neuronal cell death,axon ...
supported by the Craig H.Neilsen Foundation;the Natural Sciences and Engineering Research Council of Canada;the Canadian Institutes of Health Research(to MM);supported by a salary award from Fonds de Recherche Québec-Santé。
Spinal cord injury(SCI),second only to stroke,is the leading cause of paralysis.The ability to walk is often lost after SCI,reducing independence and quality of life.Restoration of walking is cited as a priority among...