PROTEIN_FOLDING

作品数：89被引量：111H指数：5
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Protein folding mechanism revealed by single-molecule force spectroscopy experiments被引量：1
《Biophysics Reports》2021年第5期399-412,共14页Hao Sun Zilong Guo Haiyan Hong Ping Yu Zhenyong Xue Hu Chen 
This research was supported by the National Natural Science Foundation of China(11874309 and 11474237);111 project(B16029);the Start-up grant of Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2021008).
Force spectroscopy experiments use mechanical force as a control factor to regulate the folding and unfolding process of proteins.Atomic force microscopy has been widely used to study the mechanical stability of prote...
关键词：Protein folding Free energy landscape Force spectroscopy Molten globule state Transition state 
Equilibrium folding and unfolding dynamics to reveal detailed free energy landscape of src SH3 protein by magnetic tweezers被引量：2
《Chinese Physics B》2021年第7期595-599,共5页Huanhuan Su Hao Sun Haiyan Hong Zilong Guo Ping Yu Hu Chen 
the National Natural Science Foundation of China(Grant Nos.11874309 and 11474237);the 111 Project(Grant No.B16029)。
Src SH3 protein domain is a typical two-state protein which has been confirmed by research of denaturant-induced unfolding dynamics.Force spectroscopy experiments by optical tweezers and atomic force microscopy have m...
关键词：protein folding and unfolding magnetic tweezers free energy landscape transition state 
Different potential of mean force of two-state protein GB1 and downhill protein gpW revealed by molecular dynamics simulation
《Chinese Physics B》2020年第7期99-103,共5页Xiaofeng Zhang Zilong Guo Ping Yu Qiushi Li Xin Zhou Hu Chen 
Project supported by the National Natural Science Foundation of China(Grant Nos.11874309,11474237,and 11574310);the 111 Project,China(Grant No.B16029).
Two-state folding and down-hill folding are two kinds of protein folding dynamics for small single domain proteins.Here we apply molecular dynamics(MD)simulation to the two-state protein GB1 and down-hill folding prot...
关键词：protein folding molecular dynamics simulation umbrella sampling potential of mean force 
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