PROTEIN_FOLDING

作品数：89被引量：111H指数：5
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Efficient Chemical Synthesis and Folding of Mirror-Image Tropomyosin Receptor Kinase A Using the Strategy of Removable Glycosylation Modification
《Chinese Journal of Chemistry》2024年第19期2316-2322,共7页Tongyue Wang Weiwei Shi Guo-Chao Chu Yi-Ming Li 
supported by the National Natural Science Foundation of China(Nos.22227810,22277020,22307061);China Postdoctoral Science Foundation(No.2022M721801);the Beijing Life Science Academy(No.2023000cc0130).
Comprehensive Summary The strategy of removable glycosylation modification was used to overcome the low-efficiency problem encountered in the chemical synthesis of the mirror-image D-version of the immunoglobulin(Ig)-...
关键词：Chemical protein synthesis Removable glycosylation modification Synthetic methods Protein folding D-protein 
From sequence to mechanobiology?Promises and challenges for AlphaFold 3被引量：1
《Mechanobiology in Medicine》2024年第3期1-3,共3页Francesco Zonta Sergio Pantano 
supported by Xi'an Jiaotong-Liverpool University(Research Development Fund RDF-23-01-026 to F.Z);FOCEM(MERCOSUR Structural Convergence Fund-COF 03/11)to S.P.
Interactions between macromolecules orchestrate many mechanobiology processes.However,progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures.In recen...
关键词：AlphaFold Protein folding Biological complexes Structure predictions Drug design 
Mutation in a non-force-bearing region of protein L influences force-dependent unfolding behavior
《Chinese Physics B》2024年第7期624-629,共6页蒋环杰 王艳伟 陈家媛 胡丹 潘海 郭子龙 陈虎 
supported by the National Natural Science Foundation of China(Grant Nos.12174322 to HC and 12204124 to ZG);111 Project(Grant No.B16029);the Graduate Scientific Research Foundation of Wenzhou University(Grant No.3162023003034 to JH);research grant from Wenzhou Institute。
Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dep...
关键词：protein folding magnetic tweezers protein L 
Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells被引量：2
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第3期212-232,共21页Hong CAO Xuchang ZHOU Bowen XU Han HU Jianming GUO Yuwei MA Miao WANG Nan LI Jun ZOU 
This work was supported by the National Natural Science Foundation of China(No.82071762);the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100);the 2021 Capacity Building of Shanghai Universities(No.21010503600),China。
The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu...
关键词：Endoplasmic reticulum-associated degradation(ERAD) Protein folding UBIQUITINATION Retrotranslocation 
Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding
《Aggregate》2024年第1期419-426,共8页Xiaohui Wu Fei Deng Yujie Chen Mengchen Xu Feihe Ma Linqi Shi 
National Natural Science Foundation of China,Grant/Award Numbers:51933006,52373153,52293383;National Key Research and Development Program of China,Grant/Award Number:2022YFA1205702;Haihe Laboratory of Sustainable Chemical Transformations,Grant/Award Number:YYJC202102。
Natural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein folding.However,synthesis of such molecules is a big challenge.The concept of“aggregate science”provid...
关键词：chaperone-like activity cooperative effect nanochaperones ordered aggregates protein folding 
Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly被引量：1
《Molecular Plant》2023年第12期1927-1936,共10页Ran Wang Hui Song Wenjuan Zhang Ning Wang Shijia Zhang Ruiqi Shao Cuimin Liu 
the Strategic Priority Research Program of the Chinese Academy of Sciences(grant no.XDA28030102);the National Key Research and Developmental Program of China(2021YFF1000203-14,granted to W.Z.);the National Natural Science Foundation of China(32170260).
Hexadecameric formI Rubisco,which consisting consists of eight large(RbcL)and eight small(RbcS)subunits,is the most abundant enzyme on earth.Extensive efforts to engineer an improved Rubisco to speed up its catalytic ...
关键词：RUBISCO CHAPERONE protein folding protein assembly assembly factor 
Effect of chaperone–client interaction strength on Hsp70-mediated protein folding
《Chinese Physics B》2023年第11期635-641,共7页邹禄军 陆伽俊 徐秀莲 
Project supported by the National Natural Science Foundation of China (Grant Nos. 11305139 and 11974173);the HPC Center of Nanjing University。
Protein folding in crowding cellular environment often relies on the assistance of various chaperones. Hsp70 is one of the most ubiquitous chaperones in cells. Previous studies showed that the chaperone–client intera...
关键词：protein folding molecular chaperone molecular dynamics HSP70 
Protein Structure Prediction:Challenges,Advances,and the Shift of Research Paradigms被引量：2
《Genomics, Proteomics & Bioinformatics》2023年第5期913-925,共13页Bin Huang Lupeng Kong Chao Wang Fusong Ju Qi Zhang Jianwei Zhu Tiansu Gong Haicang Zhang Chungong Yu Wei-Mou Zheng Dongbo Bu 
the National Key R&D Program of China(Grant No.2020YFA0907000)lthe National Natural Science Foundation of China(Grant Nos.32271297,62072435,31770775,and 31671369)for providing financial support for this study and publication charges.
Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields,including biochemistry,medicine,physics,mathematics,and computer science.These researchers adopt ...
关键词：Protein folding Protein structure prediction Deep learning TRANSFORMER Language model 
SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor
《Acta Pharmaceutica Sinica B》2023年第7期3043-3053,共11页Yiqun Li Mingrui Yang Yanan Nan Jiaming Wang Sanjiao Wang Dongxiao Cui Jiajian Guo Pengfei He Wenxin Dai Shuqi Zhou Yue Zhang Wenfu Ma 
supported by Startup fund program at Beijing University of Chinese Medicine(BUCM)(90011451310011,China)to Wenfu Ma;the emergency fund against COVID-19 program at BUCM(1000061223476,China)to Wenfu Ma;the innovation team and talents cultivation program of national administration of traditional Chinese medicine(ZYYCXTD-C202006,China)to Wenfu Ma。
Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S...
关键词：COPI inhibitor SARS-CoV-2 spike Spike sorting motifs Protein folding Protein trafficking Anti-COVID-19 Omicron variants and drug discovery 
HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis
《Plant Communications》2023年第3期244-257,共14页Silvina Mangano Alfonso Muñoz Lourdes Fernández-Calvino M.Mar Castellano 
supported by the project RTI2018-095946-B-I00 and PID2021-126956OB-I00 from MICIU;by"Severo Ochoa Programme for Centres of Excellence in R&D"from the Agencia Estatal de Investigación of Spain(grants SEV-2016-0672 and CEX2020-000999-S to the CBGP);In the frame of this latter program,S.M.was supported with postdoctoral contracts.We also acknowledge the grant"Recualificación del profesorado universitario"from the Ministerio de Universidades to A.M.(UCO).
Gibberellins(GAs)play important roles in multiple developmental processes and in plant response to the environment.Within the GA pathway,a central regulatory step relies on GA-dependent degradation of the DELLA transc...
关键词：HSP70-HSP90 organizing protein seed germination thermomorphogenesis RGA protein folding protein stability 
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