supported by the National Natural Science Foundation of China(Nos.22274118,22074107,and 81870359);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.22KJB320020);InnoHK funding(C2i)from Innovation&Technology Commission(ITC)of Hong Kong SAR Government。
Viral epidemics pose a serious threat to global public health,making it essential to explore virus-host interactions for uncovering the pathogenesis of viral diseases and developing effective antiviral strategies.Trad...
funded by the National Key Research and Development Program of China(No.2021YFF1200803);National Natural Science Foundation of China(No.62120106004,61901412,62271443);and China Postdoctoral Science Foundation Funded Project(2022M712783).
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening.By employing diverse types of spheroids or organoids,it is feasible to establish microphysiolog...
supported by the National Natural Science Foundation of China(22035008,21972155,22002177,and 22205244);Youth Innovation Promotion Association,Chinese Academy of Sciences(CAS)(2022027);CAS-Croucher Funding Scheme for Joint Laboratories;China Postdoctoral Science Foundation(2022M713225)。
Self-pumping dressings(SPDs)have been developed as a new type of effective material for the drainage of excessive wound exudates based on the structure of asymmetric wettability.However,current SPDs are easy to lose t...
developed under the scope of the EndoSWITCH project(PTDC/BTMORG/5154/2020);supported by the Portuguese Founda-tion for Science and Technology(FCT).The authors thanks FCT for Iasmim Orge’s PhD scholarship SFRH/BD/2020.07458;Sílvia Bidarra’s research contract DL 57/2016/CP1360/CT0006 and Silvia Ferreira’s research contract CEECINST/00132/2021/CP1774/CT0001;Iasmim Orge thanks the training provided under the scope of the REMODEL project(European Union’s Horizon 2020 research and innovation pro-gramme,grant agreement 7857491);The authors also acknowledge the support of i3S Scientific Platforms:“Bioimaging”member of the PPBI(Grant No:PPBI-POCI-01-0145-FEDER-022122);“Biointerfaces and Nanotechnology”(Grant No:UID/BIM/04293/2019);“BioSciences Screening”(member of the PT-OPENSCREEN(NORTE-01-0145-FEDER-085468);PPBI(PPBI-POCI-01-0145-FEDER-022122)).
The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regen-eration,remaining a central challenge in tissue engineering.In this study,we present a novel(micro)vascular...
the “Shanghai Beyond Limits Manufacturing Project” for supporting the realization of the BLM concept for microchip products.
This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic chips.These chip...
supported by the National Research Foundation of Korea(NRF)grant funded by the Ministry of Science and ICT(MSIT)of Korea(No.2021R1A2B5B03001416,No.2020R1A2C1100471,No.2020R1A5A8018367);the BK21 FOUR Program of the NRF grant funded by the Ministry of Education(MOE)of Korea.
In vitro vascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug screening.However,the lack of consideration and preparation methods for cancer cellular sources...
National Key Research and Development Program of China,Grant/Award Number:2022YFA1104400;National Natural Science Foundation of China,Grant/Award Numbers:81930025,82301028,82371020;China Postdoctoral Science Foundation,Grant/Award Number:BX20230485;Shaanxi Youth Science and Technology Rising Star Program,Grant/Award Number:2023KJXX-027。
Stem cells,especially mesenchymal progenitors or mesenchymal stem cells(MSCs),possess an intrinsic property to form compact spheroid-like assemblies,a phenomenon known as cell aggregation.In recent years,a growing bod...
the Shanghai Pujiang Program(21PJ1409200);the China Postdoctoral Science Foundation(2022M722122);Three-year Action Plan of Shenkang Development Center(SHDC2020CR2019B);Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiao Tong University School of Medicine(2022LHB07,2022LHA01);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System;the Fundamental Research Funds for the Central Universities(YG2023LC07);Clinical Research Program of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(JYLJ202122);the Project of Biobank from Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(YBKB202116);the National Scientific Foundation of China(82171993,81972058,82130073).
Marrow niches in osteosarcoma(OS)are a specialized microenvironment that is essential for the maintenance and regulation of OS cells.However,existing animal xenograft models are plagued by variability,complexity,and h...