supported by the National Natural Science Foundation of China (Grant No. 30830028);the National Basic Research program of China (Grant No. 2010CD833706/2010CB912400) (S.F.S.);the National Institutes of Health (Grant No. GM34766 to PCT)
SecA,the ATPase of Sec translocase,mediates the post-translational translocation of preprotein through the protein-conduct-ing channel SecYEG in the bacterial inner membrane.Here we report the structures of Escherichi...