Supported by the National Key Basic Research Program(973 program);No.2015CB554000;the National Natural Science Foundation of China,No.81302492,No.81520108021 and No.91529305
Hepatocellular carcinoma(HCC) is one of the most common and highly fatal malignancies worldwide. Chronic infection with hepatitis B virus(HBV) is a major cause of HCC. High HBV replication rate and related non-resolvi...