TRANSDUCTION

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Computational prediction and functional analysis of arsenic-binding proteins in human cells
《Quantitative Biology》2019年第3期182-189,共8页Shichao Pang Junchen Yang Yilei Zhao Yixue Li Jingfang Wang 
This work was supported by the National Key R&D Program of China(Nos.2016YFC0901704 and 2017YFA0505500);National High-Tech R&D Program(863 Program,No.2015AA020105);the National Natural Science Foundation of China(Nos.21377085 and 31770070);MOE New Century Excellent Talents in University(No.NCET-12-0354);SJTU Med-Eng Joint Program(No.YG2016MS33)for financial supports.
Background:Arsenic has a broad anti-cancer ability against hematologic malignancies and solid tumors.To systematically understand the biological functions of arsenic,we need to identify arsenic-binding proteins in hum...
关键词：arsenic-binding proteins free energy profile position-specific SCORE matrix signaling TRANSDUCTION 
Cell type specificity of signaling:view from membrane receptors distribution and their downstream transduction networks
《Protein & Cell》2012年第9期701-713,共13页Ying He Zhonghao Yu Dongya Ge Rui Wang-Sattler Hans-Jurgen Thiesen Lu Xie Yixue Li 
kindly funded by National Natural Science Foundation of China(Grant No.31070752);in part supported by the National Basic Research Program(973 Program)(Nos 2011CB910204,2010CB529206 and 2010CB912702);Key Infectious Disease Project(No.2012ZX10002012-014);Research Program of Chinese Academy of Sciences(Nos.KSCX2-EW-R-04,KSCX2-YW-R-190 and 2011KIP204);National Natural Science Foundation of China(Grant No.30900272);Chinese Ministry for Science and Technology Grant(No.2008BAI64B01);the National High Technology Research and Development Program(863 Program)(No.2009AA02Z304).
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities.To overview the specificity of cell signaling,we integrated human re...
关键词：plasma membrane receptor cellular signaling transduction network diversity cell type specific spatial expression profile 
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