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Cell type specificity of signaling:view from membrane receptors distribution and their downstream transduction networks
《Protein & Cell》2012年第9期701-713,共13页Ying He Zhonghao Yu Dongya Ge Rui Wang-Sattler Hans-Jurgen Thiesen Lu Xie Yixue Li 
kindly funded by National Natural Science Foundation of China(Grant No.31070752);in part supported by the National Basic Research Program(973 Program)(Nos 2011CB910204,2010CB529206 and 2010CB912702);Key Infectious Disease Project(No.2012ZX10002012-014);Research Program of Chinese Academy of Sciences(Nos.KSCX2-EW-R-04,KSCX2-YW-R-190 and 2011KIP204);National Natural Science Foundation of China(Grant No.30900272);Chinese Ministry for Science and Technology Grant(No.2008BAI64B01);the National High Technology Research and Development Program(863 Program)(No.2009AA02Z304).
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities.To overview the specificity of cell signaling,we integrated human re...
关键词：plasma membrane receptor cellular signaling transduction network diversity cell type specific spatial expression profile 
Interference RNA induction and drug target validation
《Journal of Chinese Pharmaceutical Sciences》2009年第4期293-301,共9页金鑫 孙婷婷 王琪 徐欢 魏铁军 贺秋晨 张礼和 周德敏 
National Natural Science Foundation of China(Grant No.20852001);"985"Project Foundation(Grant No.985-2-126-121 );The Key Laboratory Grant(Grant No.20080104);National Basic Research Program of China(Grant No.973 Program,2010CB 12300)
The ability to knockdown the expression of an endogenous gene by RNAi has emerged as a powerful strategy for the rapid identification of specific gene functions. Vector-based constitutive expression of shRNA can resul...
关键词：RNA interference Stable transduction Inducible RNAi Target validation Xenograft animal model 
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