Supported by the National Natural Science Foundation of China(No.81271697), the Science Foundation of Changchun City, China(No.09SF02), the China Postdoctoral Science Foundation(No.20100481048), the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20100061120077) and the Social Development Project of Science and Tech- nology Department of Jilin Province, China(Nos.20106031, 20120967, YYZX2012).
A new route was described to synthesize Arg-Gly-Asp-X(RGDX,X=amino acid) tetrapeptide.To better understand the method,the tetrapeptide Arg-Gly-Asp-CySS(RGDCySS) was chosen as a model target for X.First,GDCySS was ...
Supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Ministry of Education,China.
Synthesis of N-benzoyl-argininylglycylasparagine methyl ester( Bz-Arg-Gly-Asp-OMe), a precursor tripeptide of Arg-Gly-Asp) was catalyzed by papain under kinetic control, at alkaline pH, in a full aqueous medium. Th...
Supported by the Special Research Grant from the State Administration of Traditional Chinese Medicine of China( No.2004ZDZX003).
The cell adhesive motif RGD tripeptide was synthesized by using a novel chemical method. First, Gly-Asp(GD) was synthesized in two steps including the chloroacetylation of free L-aspartic acid and the ammonolysis of...