National Natural Science Foundation of China,No.82100301;Key Science and Technology Research Program of Hebei Provincial Department of Health,No,20221014.
BACKGROUND Umbilical cord(UC)mesenchymal stem cell(MSC)transplantation is a potential therapeutic intervention for atherosclerotic vascular disease.Integrin beta 3(ITGB3)promotes cell migration in several cell types.H...
supported by the National Natural Science Foundation of China under Grant Nos.51202194 and 51221001;the Programme of Introducing Talents of Discipline to Universities(‘‘111’’project of China)under Grant No.B08040
Carbon/carbon (C/C) composites were deposited with graphite-like carbon (GLC) coating, and then, Arg-Gly- Asp acid (RGD) peptides were successfully immobilized onto the functionalized GLC coating. GLC coating wa...
Summary: Integrins such as αvβ3, α5β31 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after cerebral ischemic stroke ca...
supported by the 863 Programs of China(No.2009AA03Z310);National Natural Science Foundation of China(Nos.21174166,30973419);the Ph.D.Programs Foundation of Ministry of Education of China(No.20100171110011);the Postdoctoral Foundation(No.201003370);Natural Science Foundation(Nos.9351027501000003,S2011020003140);S&T Programs of Guangdong Province(Nos.2010B031500011,2009B030803003,2009B030801107,2012B031800135);SYSU Projects for Promotion of Key and Emerging Interdisciplinary Researches(10ykjc18);Young Teachers(11lgpy44)
Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were pre...
Supported by the National Natural Science Foundation of China(No.81271697), the Science Foundation of Changchun City, China(No.09SF02), the China Postdoctoral Science Foundation(No.20100481048), the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20100061120077) and the Social Development Project of Science and Tech- nology Department of Jilin Province, China(Nos.20106031, 20120967, YYZX2012).
A new route was described to synthesize Arg-Gly-Asp-X(RGDX,X=amino acid) tetrapeptide.To better understand the method,the tetrapeptide Arg-Gly-Asp-CySS(RGDCySS) was chosen as a model target for X.First,GDCySS was ...
Background Endostatin is a potent inhibitor of tumor angiogenesis. In the preliminary studies, we developed a mutant endostatin containing Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) sequences. In this study, we compared the a...
Background Angiogenesis is an essential step for tumor development and metastasis.The cell adhesion molecule αvβ3 integrin plays an important role in angiogenesis and is a specific marker of tumor angiogenesis.A nov...