BGC

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  • 期刊=Synthetic and Systems Biotechnologyx
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Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces hosts for natural product discovery被引量：1
《Synthetic and Systems Biotechnology》2023年第2期253-261,共9页Elena Heng Lee Ling Tan Dillon W.P.Tay Yee Hwee Lim Lay-Kien Yang Deborah C.S.Seow Chung Yan Leong Veronica Ng Siew Bee Ng Yoganathan Kanagasundaram Fong Tian Wong Lokanand Koduru 
supported by National Research Foundation,Singapore(NRF-CRP19-2017-05-00);Agency for Science,Technology and Research(A*STAR),Singapore(#21719).
With the advent of rapid automated in silico identification of biosynthetic gene clusters(BGCs),genomics pre-sents vast opportunities to accelerate natural product(NP)discovery.However,prolific NP producers,Strepto-my...
关键词：Streptomyces GC-Rich Hybrid assembly Biosynthetic gene cluster(BGC) Natural product(NP)chassis Type I polyketide Synthase(PKS) 
Expression of fungal biosynthetic gene clusters in S. cerevisiae for natural product discovery
《Synthetic and Systems Biotechnology》2021年第1期20-22,共3页Zihe Liu Zhenquan Lin Jens Nielsen 
This work was supported by National Key Research and Development Program(2018YFA0901800);National Natural Science Foundation of China(22078012);Chinese Postdoctoral Science Foundation(2020M670115);the Novo Nordisk Foundation(NNF10CC1016517),the Knut and Alice Wallenberg Foundation and Beijing Advanced Innovation Center for Soft Matter Science and Engineering.
Fungi are well known for production of antibiotics and other bioactive secondary metabolites,that can be served as pharmaceuticals,therapeutic agents and industrially useful compounds.However,compared with the charact...
关键词：Natural product discovery Cross-species engineering SPLICEOSOME High-throughput BGC cloning Synthetic biology Yeast 
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