SPLICEOSOME

作品数：20被引量：33H指数：4
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相关领域：生物学更多>>
相关作者：张琳万宇峰郭金虎更多>>
相关机构：中山大学南通市肿瘤医院(南通市第五人民医院)吉林大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Acta Biochimica et Biophysica Sinica》《Molecular Plant》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Spliceosome-mediated RNA trans-splicing: a strategy for Huntington’s disease gene therapy
《BIOCELL》2024年第10期1443-1453,共11页QINGYANG ZHANG SHUXIAN HUANG DAN WENG 
National Natural Science Foundation of China under Grant 22376100.
Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production o...
关键词：Huntington’s disease Neurodegenerative disease RNA therapy TRANS-SPLICING Spliceosome-mediated RNA trans-splicing 
Structural insights into human exon-defined spliceosome prior to activation
《Cell Research》2024年第6期428-439,共12页Wenyu Zhang Xiaofeng Zhang Xiechao Zhan Rui Bai Jianlin Lei Chuangye Yan Yigong Shi 
supported by funds from the National Natural Science Foundation of China(31930059 to Y.S.);the Frontier Research Center for Biological Structure,and start-up funds from Westlake University(to Y.S.).
Spliceosome is often assembled across an exon and undergoes rearrangement to span a neighboring intron.Most states of the intron-defined spliceosome have been structurally characterized.However,the structure of a full...
关键词：ACTIVATION INSIGHT STEPWISE 
Transcriptomic and genomic identification of spliceosomal genes from Euglena gracilis
《Acta Biochimica et Biophysica Sinica》2023年第11期1740-1748,共9页Pingwei Gao Yujie Zhong Chengfu Sun 
supported by the grants from the National Natural Science Foundation of China (No.31872717);the Disciplinary Construction Innovation Team Foundation of Chengdu Medical College (No.CMC-XK-2102).
Diverse splicing types in nuclear and chloroplast genes of protist Euglena gracilis have been recognized for dec-ades.However,the splicing machinery responsible for processing nuclear precursor messenger RNA introns,i...
关键词：txcavata SPLICEOSOME INTRON TRANSCRIPTOME TRANS-SPLICING SF3B 
The Sm core protein SmEb regulates salt stress responses through maintaining proper splicing of RCD1 pre-mRNA in Arabidopsis
《Journal of Integrative Plant Biology》2023年第6期1383-1393,共11页Yechun Hong Yang Gao Jia Pang Huazhong Shi Tingting Li Huiying Meng Dali Kong Yunjuan Chen Jian-Kang Zhu Zhen Wang 
supported by the National Natural Science Foundation of China(32000206 to Z.W.and 32200234 to Y.H.);Anhui Provincial Natural Science Foundation(2208085Y08 to Z.W.);Shenzhen Science and Technology Program(RCBS20210706092213009 to Y.H.)。
Salt stress adversely impacts crop production.Several spliceosome components have been implicated in regulating salt stress responses in plants,however,the underlying molecular basis is still unclear.Here we report th...
关键词：alternative splicing RCD1 salt stress SmEb SPLICEOSOME 
The spliceophilin CYP18-2 is mainly involved in the splicing of retained introns under heat stress in Arabidopsis
《Journal of Integrative Plant Biology》2023年第5期1113-1133,共21页Areum Lee Hyun Ji Park Seung Hee Jo Haemyeong Jung Hyun-Soon Kim Hyo-Jun Lee Youn-Sung Kim Choonkyun Jung Hye Sun Cho 
funded by the New Breeding Technology program(no,PJ01686202);the National Research Foundation of Korea(NRF;No.2022R1A2B5B02002008);Research Initiative Programs of the Korea Research Institute of Bioscience and Biotechnology(KRIBB;No.5372322)grants to H.C.
Peptidyl-prolyl isomerase-like 1(PPIL1)is associated with the human spliceosome complex.However,its function in pre-mRNA splicing remains unclear.In this study,we show that Arabidopsis thaliana CYCLOPHILIN 18-2(AtCYP1...
关键词：alternative splicing CYP18-2 HSFA2-Ⅲ intron retention spliceophilin spliceosome complex B~(ACT) THERMOTOLERANCE 
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration被引量：1
《Protein & Cell》2023年第5期318-336,共19页Dawei Meng Qian Zheng Xue Zhang Xuejiao Piao Li Luo Yichang Jia 
the Tsinghua-Peking Joint Center for Life Sciences,the Thousand-Talent Young Investigator Program,the IDG/McGovern Institute for Brain Research,the National Natural Science Foundation of China(81371361,92049114,31571097,82101495);The Beijing Municipal Science&Technology Commission(Z181100001518001,Z161100000216154);National Key R&D Program(2017YFC0110205);the Institute for Guo Qiang,Tsinghua University。
Emerging evidence suggests that intron-detaining transcripts(IDTs)are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively respond to environmental stimuli and stress.However,the underly...
关键词：SNIP1 RNPS1 SPLICEOSOME detained intron NEURODEGENERATION 
Roles of alternative splicing in infectious diseases: from hosts, pathogens to their interactions被引量：1
《Chinese Medical Journal》2023年第7期767-779,共13页Mengyuan Lyu Hongli Lai Yili Wang Yanbing Zhou Yi Chen Dongsheng Wu Jie Chen Binwu Ying 
National Natural Science Foundation of China(No.82272416)
Alternative splicing(AS)is an evolutionarily conserved mechanism that removes introns and ligates exons to generate mature messenger RNAs(mRNAs),extremely improving the richness of transcriptome and proteome.Both mamm...
关键词：Alternative splicing Infectious diseases SPLICEOSOME Regulation mechanism Targeted drug 
Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells被引量：2
《Science China(Life Sciences)》2023年第3期423-435,共13页Pengfei Zhang Xuzhao Zhai Boyan Huang Shu Sun Wen Jing Wang Man Zhang 
supported by the National Natural Science Foundation of China(32070800)。
Mammalian embryogenesis begins with a totipotent zygote.Blastocyst-like structures can be captured by aggregated cells with extended pluripotent properties in a three-dimensional(3D)culture system.However,the efficien...
关键词：blastoids TBLCs early embryogenesis totipotent 
Emerging roles of spliceosome in cancer and immunity被引量：7
《Protein & Cell》2022年第8期559-579,共21页Hui Yang Bruce Beutler Duanwu Zhang 
This work was supported by the National Natural Science Founda-tion of China(No.82071780);Science and Technology Commission of Shanghai Municipality(No.20ZR1407600);Shanghai Municipal Science and Technology Majpr Project(No.2018SHZDZX03);the Zhangjiang Lab.The authors thank Anne R.Murray,PhD,MWC®for writing and editorial assistance during the preparation of this manuscript.Illustrations were mainly created with BioRender.com.
Precursor messenger RNA(pre-mRNA)splicing is cat-alyzed by an intricate ribonucleoprotein complex called the spliceosome.Although the spliceosome is consid-ered to be general cell"housekeeping"machinery,mutations in c...
关键词：SPLICEOSOME SPLICING CANCER innate immunity immune dysregulation 
Boosting the cellular potency of embryonic stem cells by spliceosome targeting
《Signal Transduction and Targeted Therapy》2021年第9期2613-2614,共2页Wilfried A.Kues 
In recent work published in Cell,Shen et al.1 identified spliceosome inhibition in embryonic stem(ES)cells as a key mechanism for the transition from pluri-to totipotency.Spliceosome inhibition,achieved by RNA interfe...
关键词：some CULTURE 
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