TRANS-SPLICING

作品数：9被引量：35H指数：3
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Spliceosome-mediated RNA trans-splicing: a strategy for Huntington’s disease gene therapy
《BIOCELL》2024年第10期1443-1453,共11页QINGYANG ZHANG SHUXIAN HUANG DAN WENG 
National Natural Science Foundation of China under Grant 22376100.
Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production o...
关键词：Huntington’s disease Neurodegenerative disease RNA therapy TRANS-SPLICING Spliceosome-mediated RNA trans-splicing 
Transcriptomic and genomic identification of spliceosomal genes from Euglena gracilis
《Acta Biochimica et Biophysica Sinica》2023年第11期1740-1748,共9页Pingwei Gao Yujie Zhong Chengfu Sun 
supported by the grants from the National Natural Science Foundation of China (No.31872717);the Disciplinary Construction Innovation Team Foundation of Chengdu Medical College (No.CMC-XK-2102).
Diverse splicing types in nuclear and chloroplast genes of protist Euglena gracilis have been recognized for dec-ades.However,the splicing machinery responsible for processing nuclear precursor messenger RNA introns,i...
关键词：txcavata SPLICEOSOME INTRON TRANSCRIPTOME TRANS-SPLICING SF3B 
Chimeric RNAs and their implication in prostate cancer
《Cancer Pathogenesis and Therapy》2023年第3期216-219,共4页Hui Li Qiong Wang 
supported by the China Scholarship Council(No.201906380075);Guangdong Province Natural Science Foundation(No.2023A1515011905).
Introduction.Specific gene fusions and their resultant fusion products,including chimeric ribonucleic acid(RNA)and protein,have long served as ideal tumor diagnostic markers and therapeutic targets.Despite this,only a...
关键词：Prostate cancer Chimeric RNAs TRANS-SPLICING Cis-SAGe 
The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans
《Journal of Genetics and Genomics》2022年第10期952-964,共13页Xinhao Hou Chengming Zhu Mingjing Xu Xiangyang Chen Cheng Sun Björn Nashan Shouhong Guang Xuezhu Feng 
supported by grants from the National Key R&D Program of China (2019YFA0802600);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39010600);the National Natural Science Foundation of China (91940303, 31870812, 32070619, 31871300 and 31900434);the China Postdoctoral Science Foundation (2018M632542);the Anhui Natural Science Foundation (1808085QC82 and 1908085QC96);supported in part by the Fundamental Research Funds for the Central Universities.
Dietary restriction usually suppresses biosynthesis but activates catabolic pathways in animals.However,the short-term starvation enhances biosynthetic activities and promotes ribosomal biogenesis in adult Caenorhabdi...
关键词：TRANS-SPLICING SNAPc tofu-5 STARVATION C.elegans 
Research Progress of Chimeric RNA and Health
《Health》2021年第4期454-471,共18页Weikai Chen Wei Cui Ye Qiu Di Cui 
With the development of deep sequencing and bioinformatics technology, a large number of products produced by abnormal RNA splicing, such as chimeric RNA and chimeric/fusion proteins, have been discovered. Natural chi...
关键词：Chimeric RNA Fusion Gene Sis-Splicing TRANS-SPLICING TUMOR HEALTH 
Evidence of constraint in the 3D genome for trans-splicing in human cells
《Science China(Life Sciences)》2020年第9期1380-1393,共14页Cong Liu Yiqun Zhang Xiaoli Li Yan Jia Feifei Li Jing Li Zhihua Zhang 
supported by the National Natural Science Foundation of China(31671342,31871331,91540114,and 31401112)。
Fusion transcripts are commonly found in eukaryotes, and many aberrant fusions are associated with severe diseases, including cancer. One class of fusion transcripts is generated by joining separate transcripts throug...
关键词：TRANS-SPLICING chromatin interaction 3D genome spatial clustering 
Gene fusions and chimeric RNAs,and their implications in cancer被引量：4
《Genes & Diseases》2019年第4期385-390,共6页Hao Wu Xiaorong Li Hui Li 
Hao Wu was supported by China Scholarship Council(CSC,No.201706370109).We thank Emily Lin for her help in creating the figure.We thank Justin Elfman for his help with English editing.
Gene fusions are appreciated as ideal cancer biomarkers and therapeutic targets.Chimeric RNAs are traditionally thought to be products of gene fusions,and thus,also cancerspecific.Recent research has demonstrated that...
关键词：Chimeric RNA cis-splicing between adjacent genes Chromosomal rearrangement Gene fusion Intergenic splicing TRANS-SPLICING 
Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene被引量：4
《Cell Research》2013年第8期1007-1024,共18页Guang-Jing Hu Jia Chen Xiao-Nan Zhao Jia-JiaXu Dong-Qing Guo Ming Lu Ming Zhu Ying Xiong Qin Li Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li 
Trans-splicing, a process involving the cleavage and joining of two separate transcripts, can expand the tran- scriptome and proteome in eukaryotes. Chimeric RNAs generated by trans-splicing are increasingly described...
关键词：TRANS-SPLICING chimeric RNA ampicillin resistance gene recombinant plasmid ACAT1 
Protein trans-splicing based dual-vector delivery of the coagulation factor Ⅷ gene被引量：27
《Science China(Life Sciences)》2010年第6期683-689,共7页ZHU FuXiang,LIU ZeLong,CHI XiaoYan & QU HuiGe Life Science College of Ludong University,Yantai 264025,China 
supported by the Natural Science Foundation of Shandong Province, China (Grant No. Y2005D14);the Science and Technology Program of Yantai (Grant No. 2008152);the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (Grant No. 20071108);the Discipline Construction Funds of Ludong University
A dual-vector system was explored for the delivery of the coagulation factor VIII gene,using intein-mediated protein trans-splicing as a means to produce intact functional factor VIII post-translationally.A pair of eu...
关键词：INTEIN protein TRANS-SPLICING coagulation factor VIII dual-vector GENE delivery 
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