This work is supported by the grants from the National Natural Science Foundation of China(31922088);Research Grant Council(N HKUST606/17,26102719,C7065-18GF,C4039-19GF);Innovation and Technology Commission(ITCPD/17-9,ITS/480/18FP);Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(SMSEGL20SC01).
The complex pattern of cancer evolution poses a huge challenge to precision oncology.Longitudinal sequencing of tumor samples allows us to monitor the dynamics of mutations that occurred during this clonal evolution p...