CHROMOSOME

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  • 学科=医药卫生—肿瘤x
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Chromosome-level genome assembly of the kiang (Equus kiang) illuminates genomic basis for its high-altitude adaptation
《Integrative Zoology》2024年第6期1199-1210,共12页Chuang ZHOU Xiaofeng ZHENG Kexin PENG Kaize FENG Bisong YUE Yongjie WU 
supported by the Second Tibetan Plateau Scientific Expedition and Research Program(No.2019QZKK0501);the National Natural Science Foundation of China(No.32270454).
The kiang(Equus kiang)can only be observed in the Qinghai–Tibet Plateau(QTP).The kiang displayed excellent athletic performance in the high-altitude environment,which attracted wide interest in the investigation of t...
关键词：chromosome-level genome high-altitude adaptation kiang missense mutation positive selection structural variation 
New genes driven by segmental duplications share a testis-specific expression pattern in the chromosome-level genome assembly of tree sparrow
《Integrative Zoology》2024年第5期1004-1008,共5页Shengnan WANG Yue SHEN Zhaocun LIN Yuquan MIAO Chengqi WANG Wenya ZHANG Yingmei ZHANG 
supported by the National Natural Science Foundation of China(No.31572216);the Foundation for Excellent Doctoral Student of Gansu Province(No.22JR5RA413).
The origination of new genes is a fundamental question in genome evolution,and gene duplication is one of the most important mechanisms for the formation of new genes(Ohno 1970;Long et al.2003;Kaessmann 2010;Ding et a...
关键词：al. SEGMENTAL pattern 
Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia
《Asian Journal of Urology》2024年第1期26-32,共7页Awad Elsid Osman Sahar Alharbi Atif Ali Ahmed Asim Ali Elbagir 
supported by King Fahad Medical City,Riyadh,Saudi Arabia(IRF No:017-059).
Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that...
关键词：Prostatecancer SAUDI Singlenucleotide polymorphism ALLELE 
Integrative Identification by Hi‑C Revealed Distinct Advanced Structural Variations in Lung Adenocarcinoma Tissue被引量：2
《Phenomics》2023年第4期390-407,共18页Tingting Song Menglin Yao Ying Yang Zhiqiang Liu Li Zhang Weimin Li 
supported by National Guided Science and Technology Development Project of Sichuan Province(No:2020ZYD009);Clinical Research Incubation Project of West China Hospital of Sichuan University(No:2018HXFH012);Hospital-enterprise cooperation clinical research innovation project(Sichuan University West China Hospital-Shanghai Pharmaceutical)(No:2019HXCX04);Sichuan Science and Technology Program(No:2020ZYD007);Science and Technology Achievement Transformation Fund of Sichuan University West China Hospital(No:CGZH19013);we sincerely thanks to Biomarker Technologies Corporation(Beijing,China)for the analyses of bioinformation in this study.
Advanced three-dimensional structure variations of chromatin in large genome fragments,such as conversion of A/B compartment,topologically associated domains(TADs)and chromatin loops are related closely to occurrence ...
关键词：High-throughput chromosome Lung cancer Advanced structural variations Chromosome 3 Tumor-related genes 
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer被引量：1
《Cancer Biology & Medicine》2022年第9期1385-1396,共12页Xu Zhang Na Qin Jingyi Fan Chang Zhang Qi Sun Yayun Gu Meng Zhu Erbao Zhang Juncheng Dai Guangfu Jin Hongxia Ma Zhibin Hu Hongbing Shen 
supported by Grants from the National Natural Science Foundation of China(Grant Nos.82103926 and 81702266);Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Grant No.81521004);Natural Science Foundation of Jiangsu Province(Grant No.BK20210534);Postdoctoral Science Foundation of China(Grant No.2021M691636);CAMS Innovation Fund for Medical Sciences(Grant No.2019RU038);Graduate Research and Innovation Program of Jiangsu Province(Grant Nos.KYCX20_1442 and KYCX20_1412).
Objective:Although our previous genome-wide association study(GWAS)has identified chromosome 2q33.1 as a susceptibility locus for non-small cell lung cancer(NSCLC),the causal variants remain unclear.The aims of this s...
关键词：Non-small cell lung cancer chromosome 2q33.1 RISK CASPASE-8 apoptosis 
Pediatric acute myeloid leukemia patients with i(17)(q10)mimicking acute promyelocytic leukemia:Two case reports
《World Journal of Clinical Cases》2022年第16期5446-5455,共10页Hong-Xia Yan Wei-Hua Zhang Jin-Quan Wen Yan-He Liu Bao-Juan Zhang A-Duo Ji 
Supported by Shaanxi Natural Science Foundation,No.2020SF-004.
BACKGROUND Chromosome i(17)(q10)abnormality is mainly associated with chronic myeloid leukemia(CML),myelodysplastic syndrome/myeloproliferative tumors(MDS/MPD),and acute myeloid leukemia(AML).The role of i(17)(q10)in ...
关键词：CHROMOSOME i(17)(q10) Gene mutations Acute promyelocytic leukemia Acute myeloid leukemia Case report 
Complete Genome Sequence of <i>Bacillus thuringiensis</i>Serovar <i>coreanensis</i>ST7 with Toxicity to Human Cancer Cells
《Advances in Microbiology》2020年第12期673-680,共8页Jing Zhang Yiping Liu Rui Liu Xu Liu Baoli Zhang Jun Zhu 
Bacillus thuringiensis (Bt) parasporal crystal proteins were well known to be toxic to certain insects and cytocidal activity against various human cancer cells. Bt serovar coreanensis ST7, non-pathogeni...
关键词：Bacillus thuringiensis Serovar Coreanensis ST7 Gapless Chromosome Plasmid Sequences Genomic Feature Cluster of Orthologous Groups of Proteins 
Alterations of chromosome 3p in 24 cases of gastrinomas and their correlations with clinicopathological and prognostic features
《Journal of Pancreatology》2020年第1期42-49,共8页Chen Yuan-Jia Ojeaburu Jeremiah V Vortmeyer Alexander Yu Shuang Jensen Robert T 
Purpose::The pathogenesis of gastrinomas is largely unknown,and there is a lack of reliable genetic determinants that are useful to distinguish malignant and benign forms of this tumor or predict the prognosis of pati...
关键词：Chromosome 3p GASTRINOMA Loss of heterozygosity Microsatellite instability Pancreatic neuroendocrine tumors 
Retrospective Cohort Study of Preimplantation Genetic Testing for Aneuploidy with Comprehensive Chromosome Screening versus Nonpreimplantation Genetic Testing in Normal Karyotype,Secondary Infertility Patients with Recurrent Pregnancy Loss被引量：7
《Reproductive and Developmental Medicine》2019年第4期205-212,共8页Cai-Xia Lei Jiang-Feng Ye Yi-Lun Sui Yue-Ping Zhang Xiao-Xi Sun 
This study was supported by Shanghai Municipal Commission of Health and Family Planning Project(No.201640365);Shanghai Shen Kang Hospital Development Center Municipal Hospital New Frontier Technology Joint Project(SHDC12017105).
Objective:To evaluate whether preimplantation genetic testing for aneuploidy(PGT-A)with comprehensive chromosome screening increases live birth rate(LBR)in normal karyotype couples with recurrent pregnancy loss(RPL).M...
关键词：Comprehensive Chromosome Screening Preimplantation Genetic Testing for Aneuploidy Recurrent Pregnancy Loss 
AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells被引量：6
《Journal of Molecular Cell Biology》2019年第9期761-769,共9页Yue Zhang Chao Wang Xiaoxu Liu Qian Yang Hongliang Ji Mengjun Yang Manman Xu Yunyan Zhou Wei Xie Zhuojuan Luo Chengqi Lin 
Thousand Young Talents Plan of China(5631006003 to C.L.,6231000011 to Z.L.);Natural Science Foundation of Jiangsu Province of China(BK20160026 to C.L.,BK20160666 and BK20170020 to Z.L.);Fundamental Research Funds for the Central Universities(3231007201 to C.L,3231008201 to Z.L.).
X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression.In female mammals,mono-allelic expression of the long non-coding RNA gene X-inac...
关键词：AFF3 XIST X CHROMOSOME inactivation DNA methylation 
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