云南高校图书馆联盟文献共享服务平台- DICHLOROACETATE

DICHLOROACETATE: 作品数：12被引量：13H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：胡志伟肖诗亮周诚肖雅琼刘金平更多>>; 相关机构：华中科技大学北京大学沈阳医学院更多>>; 相关期刊：《中华肿瘤杂志》《华中科技大学学报（医学版）》《Animal Nutrition》《Journal of Animal Science and Biotechnology》更多>>; 相关基金：国家自然科学基金湖北省自然科学基金重庆市自然科学基金国家重点基础研究发展计划更多>>

Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1αaxis and insulin sensitivity: 《Animal Nutrition》2022年第4期25-37,共13页Yuan Luo Wenhao Zhou Ruixin Li Samwel MLimbu Fang Qiao Liqiao Chen Meiling Zhang Zhen-Yu Du; the financial support provided by the National Key R&D Program of China(2018YFD0900400)。; Pyruvate dehydrogenase kinases(PDKs)-pyruvate dehydrogenase E1αsubunit(PDHE1α)axis plays an important role in regulating glucose metabolism in mammals.However,the regulatory function of PDKsPDHE1α axis in the gluco...; 关键词：DICHLOROACETATE Glucose utilization Insulin sensitivity Nile tilapia PDK2/4-PDHE1αaxis

The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy被引量：3: 《Nano Research》2021年第3期778-787,共10页Yanxin Qi Shiwei Jing Shasha He Hejian Xiong Guohua Yang Yubin Huang Ningyi Jin; This work was supported by the National Natural Science Foundation of China(Nos.51273194,21975246 and 51903233).; Chemotherapeutic and radiation therapy have emerged as two most important treatment strategies to treat cancer in clinical practice;however,to improve anticancer efficacy,combination chemotherapy still remains challen...; 关键词：fast neutron therapy DICHLOROACETATE control release combination therapy subcutaneous or orthotopic tumor model

Dichloroacetate enhances the antitumor effect of pirarubicin via regulating the ROS-JNK signaling pathway in liver cancer cells: 《Cancer Drug Resistance》2020年第4期947-958,共12页Xiao-Jing Yan Peng Xie Xu-Fang Dai Ling-Xi Chen Liang-Bo Sun Tao Li Wen-Hui He Zhi-Zhen Xu Gang Huang Feng-Tian He Ji-Qin Lian; This study was supported by the National Natural Science Foundation of China(81572375 and 81872024);the Chongqing Natural Science Foundation(cstc2018jcyjA2018).; Aim:Liver cancer is one of the most common malignancies and has a high recurrence rate.However,current treatment strategies do not achieve satisfactory outcomes in the clinic.To explore a new strategy to enhance the e...; 关键词：DICHLOROACETATE c-Jun N-terminal kinase liver cancer cells PIRARUBICIN reactive oxygen species

Effects of adding sodium dichloroacetate to low-protein diets on nitrogen balance and amino acid metabolism in the portaldrained viscera and liver of pigs被引量：2: 《Journal of Animal Science and Biotechnology》2020年第3期884-895,共12页Weizhong Sun Yunxia Li Zhiru Tang Huiyuan Chen Ke Wan Rui An Liuting Wu Zhihong Sun; This study was funded by grants from the National Natural Science Foundation of China(31872370,31670123);the Fundamental Research Funds for the Central Universities(XDJK2019B014,XDJK2013C097);the Natural Science Foundation Project of CQ CSTC(cstc2018jcyjAX0025).; Background:Identifying regulatory measures to promote glucose oxidative metabolism while simultaneously reducing amino acid oxidative metabolism is one of the foremost challenges in formulating low-protein(LP)diets de...; 关键词：Amino acid metabolism Low-protein diet Nitrogen excretion PIG Sodium dichloroacetate

Sodium dichloroacetate could inhibit the endothelial-to-mesenchymal transition:a novel treatment target for pulmonary arterial hypertension: 《中国循环杂志》2018年第S01期166-166,共1页Wen Li Li Huang Tao Yang Li Li Qing Gu Changming Xiong Xianmin Meng Jianguo He; Background and Purpose Recent studies found endothelialto-mesenchymal transition(EndoMT)played an important role in the pathogenesis of pulmonary arterial hypertension.Our pilot research demonstrated the existence of ...; 关键词：pulmonary ARTERIAL hypertension endothelialto-mesenchymal transition DICHLOROACETATE

Long-term stabilization of metastatic melanoma with sodium dichloroacetate: 《World Journal of Clinical Oncology》2017年第4期371-377,共7页Akbar Khan Doug Andrews Jill Shainhouse Anneke C Blackburn; Sodium dichloroacetate(DCA) has been studied as a metabolic cancer therapy since 2007, based on a publication from Bonnet et al demonstrating that DCA can induce apoptosis(programmed cell death) in human breast, lung ...; 关键词：DICHLOROACETATE Cancer BRAF MELANOMA CYTOSTATIC

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy被引量：4: 《World Journal of Clinical Cases》2016年第10期336-343,共8页Akbar Khan Douglas Andrews Anneke C Blackburn; Oral dichloroacetate sodium(DCA) has been investigated as a novel metabolic therapy for various cancers since 2007, based on data from Bonnet et al that DCA can trigger apoptosis of human lung, breast and brain cancer...; 关键词：DICHLOROACETATE Cancer COLON Colorectal CYTOSTATIC STABILIZATION Growth inhibition INTRAVENOUS

Effects of dichloroacetate on the activation of the mitochondrial pathway in C6 cells in vitro: 《Journal of Chinese Pharmaceutical Sciences》2011年第5期460-465,共6页赵欣王欣余克富段瑀李捷思赵炳祥张烜张强; National Natural Science Foundation of China (Grant No.30873170);the National Basic Research Program of China(973 Program 2007CB935800 and 2009CB930300); Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochond...; 关键词：Mitochondria metabolism DICHLOROACETATE C6 glioma Pyruvate dehydrogenase Reactive oxygen species Mitochondrial membrane potential

Dichloroacetate as a potential metabolic-targeting therapy for cancer: 《中华肿瘤杂志》2008年第12期M0004-M0004,共1页; 关键词：二氯乙酰氯代谢性酸中毒醣酵解临床治疗

DCA降低家兔血乳酸值的实验研究: 《中国现代应用药学》2000年第3期215-217,共3页江敏王学林张辉祖新琳苏露晖伊德林; 目的 :为研究Dichloroacetate(DCA)降低血乳酸的疗效。方法 :采用作者改良的BarKer氏法观测正常及高乳酸血症 (HLA)家兔血乳酸值在接受DCA后的动态变化。结果 :静脉注射DCA( 50mg/kg)后 1 5及 3 0min时 ,正常 (P<0 .0 5)与HLA家兔血乳酸...; 关键词：DICHLOROACETATE 乳酸高乳酸血症二氢乙酸盐

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